The Clinicopathological Factors Associated with Multicentricity in Papillary Thyroid Cancer

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dc.contributor.authorKilic, Murat Ozgur
dc.contributor.authorBilgic, Celal Ismail
dc.contributor.authorDener, Cenap
dc.contributor.authorIcen, Duygu
dc.date.accessioned2025-10-24T18:10:01Z
dc.date.available2025-10-24T18:10:01Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAim: Multicentricity is a frequent feature of papillary thyroid cancer, and is generally associated with advanced stage, increased risk of regional and distant metastasis. In this study, we aimed to determine the associated clinicopathological factors on multicentricity in papillary thyroid cancer. Material and Method: One hundred and thirty patients with papillary thyroid cancer were included in this retrospective study. The affecting clinical and histopathological factors on multicentricity were investigated. Results: Total thyroidectomy with or without central/lateral neck dissection was performed in 130 patients (101, 77.7% were female and 29, 22.3% were male) with a mean age of 43.03 years. The diagnosis of papillary thyroid cancer was confirmed by final histopathology in all cases. Multicentricity and bilaterality were detected in 54 (41.5%) and 16 (12.3%) patients, respectively. Tumor size (p= 0.046) and perineural invasion (p= 0.020) were significantly different between the patients with multicentric cancer and those with solitary cancer. Discussion: According to the findings obtained from this study, tumor size and perineural invasion were the affecting factors on multicentricity in papillary thyroid cancer. However, large-scale, multicenter clinical and genetic studies are needed to clearly determine the affecting factors on multicentricity of these cancers.
dc.identifier.doi10.4328/JCAM.4256
dc.identifier.endpage482
dc.identifier.issn1309-0720
dc.identifier.issn1309-2014
dc.identifier.issue4
dc.identifier.scopus2-s2.0-84962028174
dc.identifier.scopusqualityN/A
dc.identifier.startpage479
dc.identifier.trdizinid209380
dc.identifier.urihttps://doi.org/10.4328/JCAM.4256
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/209380
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3945
dc.identifier.volume7
dc.identifier.wosWOS:000376567100014
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-
dc.language.isoen
dc.publisherDerman Medical Publ
dc.relation.ispartofJournal Of Clinical And Analytical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectBilaterality; Multicentricity; Papillary Thyroid Cancer
dc.titleThe Clinicopathological Factors Associated with Multicentricity in Papillary Thyroid Cancer
dc.title.alternativePapiller tiroid kanserinde multisentrisite ile ilişkili klinikopatolojik faktörler
dc.typeArticle

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