Increased levels of serum granzyme-B is associated with insulin resistance and increased cardiovascular risk in adolescent polycystic ovary syndrome patients

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dc.authoridTokmak, Aytekin/0000-0001-5739-5689|Yilmaz, Nafiye/0000-0002-4041-297X
dc.contributor.authorOztas, Efser
dc.contributor.authorOzler, Sibel
dc.contributor.authorTokmak, Aytekin
dc.contributor.authorYilmaz, Nafiye
dc.contributor.authorCelik, Huseyin Tugrul
dc.contributor.authorKazanci, Fatmanur Hacievliyagil
dc.contributor.authorDanisman, Nuri
dc.date.accessioned2025-10-24T18:09:00Z
dc.date.available2025-10-24T18:09:00Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjectives: Our aim was to determine serum perforin and granzyme-B levels in adolescent PCOS patients, and to investigate whether they are associated with some of the insulin sensitivity, obesity and cardiovascular (CV) risk markers and metabolic syndrome. Study design: A case-control study was carried out including a total of 172 adolescents (83 PCOS patients and 89 age-matched healthy controls). Participants were recruited consecutively. Homeostasis model assessment (HOMA-IR), lipid parameters, and anthropometric measurements were determined. Serum perforin and granzyme B levels were measured by commercially available ELISA kits. HOMA-IR > 3.16 was considered to indicate the presence of insulin resistance. Logistic regression analysis was applied for the predictive value of granzyme-B for increased CV risk in PCOS patients. Results: As body mass index (BMI) of the PCOS patients was significantly higher than the controls (median 24.6 kg/m(2) and 21.4 kg/m(2), respectively, p < 0.001) all parameters were evaluated after adjustment for BMI. Adolescents with PCOS had significantly higher levels of fasting glucose, insulin, HOMA-IR and granzyme-B when compared with controls. According to the results of logistic regression analysis, granzyme-B levels were found to be significantly associated with increased HOMA-IR (OR = 6.120, 95% CI: 2.352-15.926, p < 0.001) in adolescent PCOS patients. Additionally, elevated levels of serum granzyme-B were predictive for increased CV risk in PCOS patients (OR = 0.237, 95% CI: 0.091-0.616, p = 0.003). Conclusions: Increased levels of serum granzyme-B are independently associated with insulin resistance and also with increased CV risk in adolescent polycystic ovary syndrome patients. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
dc.identifier.doi10.1016/j.ejogrb.2016.01.009
dc.identifier.endpage93
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.pmid26802256
dc.identifier.scopus2-s2.0-84959377843
dc.identifier.scopusqualityQ2
dc.identifier.startpage89
dc.identifier.urihttps://doi.org/10.1016/j.ejogrb.2016.01.009
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3418
dc.identifier.volume198
dc.identifier.wosWOS:000371836500017
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofEuropean Journal Of Obstetrics & Gynecology And Reproductive Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectAdolescent polycystic ovary syndrome; Cardiovascular risk; Granzyme-B; Insulin resistance; Perforin
dc.titleIncreased levels of serum granzyme-B is associated with insulin resistance and increased cardiovascular risk in adolescent polycystic ovary syndrome patients
dc.typeArticle

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