Synthesis and evaluation of anticancer properties of novel benzimidazole ligand and their cobalt(II) and zinc(II) complexes against cancer cell lines A-2780 and DU-145

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dc.authorid0000-0002-2806-4781en_US
dc.authorid0000-0002-8916-3329en_US
dc.contributor.authorYılmaz, Ülkü
dc.contributor.authorTekin, Suat
dc.contributor.authorBuğday, Nesrin
dc.contributor.authorYavuz, Kemal
dc.contributor.authorKüçükbay, Hasan
dc.contributor.authorSandal, Süleyman
dc.date.accessioned2021-08-25T18:37:19Z
dc.date.available2021-08-25T18:37:19Z
dc.date.issued2019en_US
dc.departmentMTÖ Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Mühendislik Temel Bilimleri Bölümüen_US
dc.description.abstractEighteen new cobalt(II) or zinc(II) complexes of benzimidazole bearing 1-benzyl and 2-phenyl moieties were synthesized from the reaction of appropriate benzimidazole ligands and CoCl2 or ZnCl2. Their structural characterizations were done by IR, NMR (1H, 13C) and UV–VIS spectrometers. Cytotoxic activities of eighteen new complexes and three benzimidazole ligands were determined using A-2780 (human ovarian) and DU-145 (human prostate) cell lines. Antitumor properties of all compounds were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell viability assay for the tested benzimidazole derivatives was performed and the LogIC50 values of the compounds were calculated after a 24-hour treatment. All tested benzimidazole derivatives showed higher or comparable antitumor activity against A-2780 cell lines compared to the standard drug docetaxel with a LogIC50 value of ?0.81?µM (p?<?0.05). Eight of the examined compounds (1, 3, 5, 6, 7, 9, 10 and 13) showed high cytotoxic activity against A-2780 compared to the standard drug docetaxel. While the LogIC50 of the docetaxel was ?0.81?µM for A-2780 cells at 24?h, the IC50 values of compounds 1, 3, 5, 6, 7, 9, 10 and 13 were ?0.97, ?1.30, ?0.22, 0.13, ?0.16, ?0.73 and ?0.53?µM, respectively. Three of the compounds 1, 18 and V showed high cytotoxic activity against DU-145 compared to docetaxel (p?<?0.05). While the LogIC50 of the docetaxel was ?1.13?µM for DU-145 cells at 24?h, the LogIC50 values of compounds 1, 18 and V were 0.84, ?0.38 and ?0.66?µM, respectively.en_US
dc.identifier.citationYılmaz, Ü., Tekin, S., Buğday, N., Yavuz, K., Küçükbay, H., & Sandal, S. (2019). Synthesis and evaluation of anticancer properties of novel benzimidazole ligand and their cobalt (II) and zinc (II) complexes against cancer cell lines A-2780 and DU-145. Inorganica Chimica Acta, 495, 118977.en_US
dc.identifier.doi10.1016/j.ica.2019.118977
dc.identifier.endpage7en_US
dc.identifier.issn0020-1693en_US
dc.identifier.issn1873-3255en_US
dc.identifier.scopus2-s2.0-85067980264en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.ica.2019.118977
dc.identifier.urihttps://hdl.handle.net/20.500.12899/359
dc.identifier.volume495en_US
dc.identifier.wosWOS:000481728800045en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYılmaz, Ülkü
dc.institutionauthorSandal, Süleyman
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofInorganica Chimica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzimidazole complexesen_US
dc.subjectCytotoxicen_US
dc.subjectA-2780 cell linesen_US
dc.subjectDU-145 cell linesen_US
dc.titleSynthesis and evaluation of anticancer properties of novel benzimidazole ligand and their cobalt(II) and zinc(II) complexes against cancer cell lines A-2780 and DU-145en_US
dc.typeArticleen_US

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