Could ferritin, vitamin B12, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
sciendo
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction. Fibromyalgia syndrome (FS) comprises general body pain, sleep disturbances, and fatigue. Vitamin B12 (VB), vitamin D (VD), and iron deficiencies lead to similar complaints. First, this study aimed to evaluate the VB, VD, and ferritin levels of patients with FS. Second, it aimed to investigate whether there was a relationship between these parameters and FS severity. Material and methods. The study included 58 female patients with FS and 58 healthy females as a control group. The patients completed the Fibromyalgia Impact Questionnaire (FIQ), Visual Analog Scale (VAS), fatigue questionnaire, Pittsburgh sleep quality scale, and the Short Form36 (SF-36). This study examined the VD, VB, and ferritin levels of the patient and control groups. Results. The VB (240.0 [110.0–394.0] vs 291.0 [210.0–609.0] pg/ml, p<0.001), VD (12.5 [3.0–45.0] vs 20.0 [5.0–54.0] ng/ml, p=0.013), and ferritin levels (21.2 [4.0–86.0] vs 32.0 [7.1–120.0], ng/ml, p=0.009) of the FS patients were determined to be significantly lower than those of the control group. A negative correlation was determined between the number of tender points and VB, VD, and ferritin levels. In the regression analysis, we found low ferritin levels (odds ratio [OR] 1.036, 95% confidence interval [CI] 1.015–1.058, p<0.001) and VB (OR 1.010, CI 1.002–1.018, p=0.010) to be an independent risk factor form FS. Conclusions. There may be a relationship between VB, VD, and ferritin levels and the number of tender points in patients with FS. Levels of iron and VB may play a vital role in FS etiopathogenesis. However, VD levels may not be a risk factor for FS etiopathogenesis
Açıklama
Anahtar Kelimeler
fibromyalgia, vitamin B12, vitamin D, iron, anemia
Kaynak
Romanian Journal of Internal Medicine
WoS Q Değeri
Scopus Q Değeri
Cilt
59
Sayı
4
Künye
Kucuk, A., Baykara, R. A., Tuzcu, A., Omma, A., Cure, M. C., Cure, E., ... & Dogan, E. (2021). Could ferritin, vitamin B, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?. Romanian Journal of Internal Medicine, 59(4), 384-393.
