The Role of ADAMTS1 and Versican in Human Myocardial Infarction: A Postmortem Study

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dc.authoridGurses, Murat Serdar/0000-0002-9982-0476|Turkmen Inanir, Nursel/0000-0002-4047-6455;
dc.contributor.authorPehlivan, Sultan
dc.contributor.authorGurses, Murat Serdar
dc.contributor.authorUral, Mustafa Numan
dc.contributor.authorAkyol, Sumeyya
dc.contributor.authorEren, Filiz
dc.contributor.authorInanir, Nursel Turkmen
dc.contributor.authorGulec, Mehmet Akif
dc.date.accessioned2025-10-24T18:09:16Z
dc.date.available2025-10-24T18:09:16Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: To determine the role of a disintegrin and metalloproteinase with thrombospondin type 1 motif (ADAMTS1) and fragmented versican in the myocardial infarction (MI) process in humans and to evaluate the diagnostic efficacy of ADAMTS1 for postmortem diagnosis of MI. Methods: Thirty autopsied individuals were allocated into 2 groups, namely, a study group of individuals who died of myocardial infarction (n = 20), and a control group who died of trauma (n = 10). We performed standard immunohistochemical staining on myocardial tissue specimens, studying anti-ADAMTS1, anti-versican, and anti-versican C terminal peptide sequence (DPEAAE) fragments. Results: Strong, diffuse staining was observed throughout myocardial tissue for ADAMTS1 in the 2 groups. However, in the study group, we observed no expression for ADAMTS1 around fibrotic areas but detected slight staining in coagulative and necrotic zones. Conclusion: Similar localizations of ADAMTS and fragmented versican in human heart tissue indicate that versican presumably is cleaved by ADAMTS1. Hence, ADAMTS1 can be regarded as a new marker for postmortem differential diagnosis of MI.
dc.identifier.doi10.1093/labmed/lmw022
dc.identifier.endpage212
dc.identifier.issn0007-5027
dc.identifier.issn1943-7730
dc.identifier.issue3
dc.identifier.pmid27346868
dc.identifier.scopus2-s2.0-85014440250
dc.identifier.scopusqualityQ3
dc.identifier.startpage205
dc.identifier.urihttps://doi.org/10.1093/labmed/lmw022
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3561
dc.identifier.volume47
dc.identifier.wosWOS:000381879800007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherOxford Univ Press
dc.relation.ispartofLaboratory Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectADAMTS1; myocardial infarction; versican; fragmented versican; postmortem; diagnosis
dc.titleThe Role of ADAMTS1 and Versican in Human Myocardial Infarction: A Postmortem Study
dc.typeArticle

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