Relationship of late arteriovenous fistula stenosis with soluble E-selectin and soluble EPCR in chronic hemodialysis patients with arteriovenous fistula

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dc.authoridBilgic, Celal Ismail/0000-0003-0434-8672|Bilgic, Mukadder Ayse/0000-0003-0621-8273
dc.contributor.authorBilgic, Mukadder Ayse
dc.contributor.authorYilmaz, Hakki
dc.contributor.authorBozkurt, Alper
dc.contributor.authorCelik, Huseyin Tugrul
dc.contributor.authorBilgic, Ismail Celal
dc.contributor.authorGurel, Ozgul Malcok
dc.contributor.authorKirbas, Ismail
dc.date.accessioned2025-10-24T18:08:49Z
dc.date.available2025-10-24T18:08:49Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractVascular access dysfunction caused by stenosis is a major complication for hemodialysis (HD) patients. However, physiopathology of late arteriovenous fistula (AVF) stenosis is still under investigation. The aim of the present study was to evaluate the association between plasma soluble EPCR (sEPCR) with serum soluble E-selectin (sE-selectin) concentration and late AVF stenosis in HD patients. Plasma sEPCR and serum sE-selectin concentrations were measured in 94 HD patients. Using these data, we studied the association of sEPCR and sE-selectin with the presence and degree of AVF stenosis using ultrasonography and fistulogram. Fifty-one patients have AVF stenosis, and the others (n = 43) have patent AVF. The degree of AVF stenosis was correlated with serum sE-selectin levels (r = 0.351, p = 0.01), but not sEPCR (r = 0.075, p = 0.702). The median level of sE-selectin was statistically higher in the group of AVF stenosis than in the group of patent AVF [463.2 pg/ml (275.4-671.4) vs. 162.5 pg/ml (96.7-285.3), p = 0.001]. Increased sE-selectin levels [OR (OR) = 6.356, p = 0.015] and high levels of LDL (OR = 4.321, p = 0.044) were independent predictors of late AVF stenosis in the multivariate model. sE-selectin and the LDL were the most important predictors of late AVF stenosis. In addition, sE-selectin correlated with the degree of AVF stenosis. We suggested that atherosclerosis might be contributing factor for development of late AVF stenosis.
dc.description.sponsorshipScientific Research Fund of Turgut Ozal University
dc.description.sponsorshipThis study was supported by the Scientific Research Fund of Turgut Ozal University.
dc.identifier.doi10.1007/s10157-014-0955-4
dc.identifier.endpage139
dc.identifier.issn1342-1751
dc.identifier.issn1437-7799
dc.identifier.issue1
dc.identifier.pmid24627030
dc.identifier.scopus2-s2.0-84895852452
dc.identifier.scopusqualityQ2
dc.identifier.startpage133
dc.identifier.urihttps://doi.org/10.1007/s10157-014-0955-4
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3325
dc.identifier.volume19
dc.identifier.wosWOS:000350230700013
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofClinical And Experimental Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectArteriovenous fistula stenosis; Biomarkers; End-stage renal disease; Angiography
dc.titleRelationship of late arteriovenous fistula stenosis with soluble E-selectin and soluble EPCR in chronic hemodialysis patients with arteriovenous fistula
dc.typeArticle

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