Association of 5-HT1A and 5-HT1B Gene Polymorphisms with Obsessive-Compulsive Disorder in a Turkish Population

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dc.authoridacar, muradiye/0000-0003-4357-5229;
dc.contributor.authorAldemir, Secil
dc.contributor.authorAcar, Muradiye
dc.contributor.authorOcak, Zeynep
dc.contributor.authorDalbudak, Ercan
dc.contributor.authorYigitoglu, Muhammet Ramazan
dc.contributor.authorGunduz, Esra
dc.date.accessioned2025-10-24T18:10:09Z
dc.date.available2025-10-24T18:10:09Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: Obsessive-compulsive disorder (OCD) is a frequent neuropsychiatric disorder, in which genetic factors play important causative roles. We investigated the roles of the (-1019 C/G) promoter region polymorphism of 5-HTR1A and the G861C coding region polymorphism of 5-HTR1B genes in susceptibility to OCD in a Turkish population. Methods: Two single nucleotide polymorphisms, 5-HTR1A (rs6296) and 5-HTR1B (rs6295) genes were genotyped in 76 OCD patients and 57 healthy controls that were unrelated, using PCR-RFLP method. Results: We did not observe any difference in the genotype distributions of rs6296 and rs6295 between the OCD patient and control groups. Conclusions: As far as we know, our study is the first to establish the association of genetic variants 5-HTR1A (rs6296) and 5-HTR1B (rs6295) with OCD in a Turkish population. Based on our results, the relationship between polymorphisms of 5-HTR1A (rs6296) and 5-HTR1B (rs6295) with OCD do not seem.
dc.identifier.doi10.5455/bcp.20151003063454
dc.identifier.endpage140
dc.identifier.issn1017-7833
dc.identifier.issue2
dc.identifier.scopus2-s2.0-84975486778
dc.identifier.scopusqualityN/A
dc.identifier.startpage134
dc.identifier.trdizinid201005
dc.identifier.urihttps://doi.org/10.5455/bcp.20151003063454
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/201005
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4011
dc.identifier.volume26
dc.identifier.wosWOS:000383390400006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-
dc.language.isoen
dc.publisherKure Iletisim Grubu A S
dc.relation.ispartofKlinik Psikofarmakoloji Bulteni-Bulletin Of Clinical Psychopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectgenetics; OCD; 5HTT gene
dc.titleAssociation of 5-HT1A and 5-HT1B Gene Polymorphisms with Obsessive-Compulsive Disorder in a Turkish Population
dc.typeArticle

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