Serum levels of endocan correlate with the presence and severity of pre-eclampsia

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dc.authoridozdemir, ozhan/0000-0002-0930-775X|ATALAY, CEMAL RESAT/0000-0002-0148-0945|Darcin, Tahir/0000-0001-5073-1790
dc.contributor.authorCakmak, Muzaffer
dc.contributor.authorYilmaz, Hakki
dc.contributor.authorBaglar, Esra
dc.contributor.authorDarcin, Tahir
dc.contributor.authorInan, Osman
dc.contributor.authorAktas, Aynur
dc.contributor.authorCelik, Huseyin Tugrul
dc.date.accessioned2025-10-24T18:09:45Z
dc.date.available2025-10-24T18:09:45Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground: Endocan, a cysteine-rich dermatan sulfate proteoglycan expressed by endothelial cells, is seemed to be a new biomarker for endothelial dysfunction. Pre-eclampsia (PE) is characterized by the new onset of hypertension, proteinuria after 20 weeks of gestation, placental vascular remodeling, systemic vascular inflammation and endothelial dysfunction. The aim of this study was to investigate the relationship of PE and its severity with serum endocan levels. Methods: A cross-sectional study was performed. Serum was collected from women with PE and normotensive controls. Serum endocan and tumor necrosis factor alpha (TNF-alpha) concentrations were measured by a specific enzyme linked immunosorbent assay. Results: Patients with PE had significantly higher median (interquartile range) endocan and mean TNF-alpha concentrations than controls [20.04 (12.26) ng/mL vs 15.55 (6.19) ng/mL, p < 0.001 for endocan; 26.49 +/- 12.14 pg/mL vs 14.62 +/- 5.61 pg/mL, p < 0.001 for TNF-alpha; respectively]. Serum endocan concentrations were positively correlated with systolic blood pressure (r = 0.618, p < 0.001), diastolic blood pressure (r = 0.608, p < 0.001), the amount of 24-h proteinuria (r = 0.786, p < 0.001) and TNF-alpha (r = 0.474, p < 0.001) in women with PE. In subgroup analysis, patients with severe PE had significantly higher endocan concentrations than those with mild PE. Receiver operating characteristic analysis of endocan was used to identify the patients with PE and also discriminating between mild and severe PE. Conclusion: Serum endocan concentrations were significantly elevated in women with PE versus normotensive controls, and concentrations seem to be associated with the severity of the disease.
dc.identifier.doi10.3109/10641963.2015.1060993
dc.identifier.endpage142
dc.identifier.issn1064-1963
dc.identifier.issn1525-6006
dc.identifier.issue2
dc.identifier.pmid26418319
dc.identifier.scopus2-s2.0-84959569627
dc.identifier.scopusqualityQ2
dc.identifier.startpage137
dc.identifier.urihttps://doi.org/10.3109/10641963.2015.1060993
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3798
dc.identifier.volume38
dc.identifier.wosWOS:000371249200003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofClinical And Experimental Hypertension
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectpre-eclampsia; biomarker; pregnancy; proteinuria; Endocan
dc.titleSerum levels of endocan correlate with the presence and severity of pre-eclampsia
dc.typeArticle

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