The role of mean platelet volume as an inflammatory marker in children with chronic spontaneous urticaria

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dc.authoridKanburoglu, Mehmet Kenan/0000-0001-6859-6689|Akelma, Zulfikar/0000-0003-0140-5053
dc.contributor.authorAkelma, A. Z.
dc.contributor.authorMete, E.
dc.contributor.authorCizmeci, M. N.
dc.contributor.authorKanburoglu, M. K.
dc.contributor.authorMalli, D. D.
dc.contributor.authorBozkaya, D.
dc.date.accessioned2025-10-24T18:08:55Z
dc.date.available2025-10-24T18:08:55Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground: Previous studies have shown that platelets are involved in the inflammatory process. Mean platelet volume (MPV) has been frequently used as an inflammatory marker in various diseases associated with inflammation. The role of MPV in children with chronic spontaneous urticaria (CU), however, has not yet been evaluated. In this study we compared MPV levels between children with and without CU. Methods: Children with CU and age-matched healthy children were enrolled in the study. Complete blood count and C-reactive protein (CRP) levels were assessed in children with CU whilst MPV levels were compared between children with and without CU. Results: Forty children with CU (19 males; mean age: 8.0 +/- 3.8 year; range: 3-15 years) and 40 healthy children (17 males; mean age: 6.9 +/- 3.0 year; range: 2-14 year) were enrolled on the prospective, case-control study. MPV (fL) levels were significantly lower in children with CU when compared to healthy children (7.42 +/- 0.77 and 7.89 +/- 0.65, respectively; p=0.004). Both mean platelet number and median CRP levels were significantly higher in children with CU when compared to healthy children (p=0008, p=0.014, respectively). Conclusion: To our knowledge, this study is the first to evaluate the role of MPV as an inflammatory marker in children with CU. A decline in MPV may be considered as an indicator of inflammation in children with CU. (C) 2013 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.
dc.identifier.doi10.1016/j.aller.2013.06.002
dc.identifier.endpage13
dc.identifier.issn0301-0546
dc.identifier.issn1578-1267
dc.identifier.issue1
dc.identifier.pmid23969073
dc.identifier.scopus2-s2.0-84921564587
dc.identifier.scopusqualityQ3
dc.identifier.startpage10
dc.identifier.urihttps://doi.org/10.1016/j.aller.2013.06.002
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3373
dc.identifier.volume43
dc.identifier.wosWOS:000349067400002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Doyma Sl
dc.relation.ispartofAllergologia Et Immunopathologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectChildren; Mean platelet volume; Platelet; Chronic spontaneous urticaria; Inflammation
dc.titleThe role of mean platelet volume as an inflammatory marker in children with chronic spontaneous urticaria
dc.typeArticle

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