The Value of HALP Score, SII, and SIRI in Predicting the Need for Intensive Care and Assessing Disease Severity in Pediatric Diabetic Ketoacidosis Cases

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dc.contributor.authorSinanoglu, Muhammed Selcuk
dc.contributor.authorDolanbay, Turgut
dc.contributor.authorDemir, Bilgehan
dc.contributor.authorNogay, Suleyman
dc.contributor.authorCeliloglu, Can
dc.contributor.authorPolat, Muhammed Eyyub
dc.date.accessioned2026-06-19T06:37:52Z
dc.date.available2026-06-19T06:37:52Z
dc.date.issued2025
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: The aim of this study was to evaluate whether Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) scores, the Systemic Immune-Inflammation Index (SII), and the Systemic Inflammatory Response Index (SIRI) can predict intensive care unit (ICU) or inpatient admissions in pediatric diabetic ketoacidosis (DKA) cases and to determine their sensitivity and specificity. Methods: This retrospective study included 39 pediatric patients (<18 years) diagnosed with DKA (pH < 7.3, HCO3 < 15). HALP, SII, SIRI, and urine ketone values were collected from medical records. Statistical analyses included ROC curve analysis, correlation tests, and appropriate parametric or non-parametric comparisons to evaluate associations with 30-day outcomes. Results: The median age was 13 years (IQR: 8-15), 56.4% were male, and 64.1% required ICU monitoring. ICU patients had significantly lower pH (p = 0.005) and HCO3 (p = 0.012) and significantly higher monocyte, SII, and SIRI values (all p <= 0.018). ROC analysis showed SIRI had the highest predictive power for ICU admission (cut-off: 3911; sensitivity: 76%; specificity: 85.7%), followed by SII. HALP scores did not demonstrate any value in assessingdisease severity for predicting ICU admission (AUC = 0.25). Conclusion: SIRI and SII are reliable predictors of ICU admission in pediatric DKA. HALP scores do not predict ICU admission and should not be considered a marker of disease severity. Incorporating SIRI and SII into clinical decision-making may improve early risk stratification. Prospective multicenter studies are warranted to validate these results.
dc.identifier.doi10.3390/children12111445
dc.identifier.issn2227-9067
dc.identifier.issue11
dc.identifier.orcid0000-0003-1596-4323
dc.identifier.orcid0000-0003-3458-2398
dc.identifier.orcid0000-0002-8799-4065
dc.identifier.pmid41300563
dc.identifier.scopus2-s2.0-105023088771
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/children12111445
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5239
dc.identifier.volume12
dc.identifier.wosWOS:001625554900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofChildren-Basel
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260612
dc.subjectCritical Care
dc.subjectDiabetic Ketoacidosis
dc.subjectHalp Score
dc.subjectInflammatory Index
dc.subjectPediatrics
dc.titleThe Value of HALP Score, SII, and SIRI in Predicting the Need for Intensive Care and Assessing Disease Severity in Pediatric Diabetic Ketoacidosis Cases
dc.typeArticle

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