Acute effects of caffeine on choroidal thickness and ocular pulse amplitude

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dc.authoriddervisogullari, mehmet serdar/0000-0003-2006-2906;
dc.contributor.authorDervisogullari, Mehmet Serdar
dc.contributor.authorTotan, Yuksel
dc.contributor.authorYuce, Aslihan
dc.contributor.authorKulak, Ali Ender
dc.date.accessioned2025-10-24T18:09:45Z
dc.date.available2025-10-24T18:09:45Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: To explore ocular changes in healthy people after caffeine consumption.Methods: This prospective observational study was carried out with students of the Turgut ozal University Medical Faculty from May 15 to 15 December 2014. Enrolled in the study were 17 healthy subjects (n=17 eyes), with a median age of 24 (IQR 1), ranging between 21 and 26 years. The control group (6 females, 11 males) aged between 23 and 28 (median 25 years [IQR 4.75]). For study, one eye from each participant was randomly selected. To obviate the effect of diurnal variations, tests were performed at the same time of the day (10:00a.m.-12:00p.m.). Each subject was given an ophthalmologic examination before the study to exclude those with undiagnosed ocular disease. Version 6.0 Cirrus high-definition optical coherence tomography (HD-OCT) (Carl Zeiss Meditec, Dublin, CA) was used to measure CT at the fovea, and 1500m nasal and 1500m temporal to the fovea. After baseline OCT measurements, participants were asked to have 200mg oral caffeine intake or a placebo capsule (200mg lactose powder). Two further OCT measurements were applied at the first and fourth hours of caffeine intake. All participants also had intraocular pressure (IOP) and ocular pulse amplitude (OPA) measurements recorded before, first and fourth hours of caffeine intake. IOP and OPA were measured using the dynamic contour tonometry (DCT) (Swiss Micro Technology AG, Port, Switzerland).Results: The groups showed no significant difference by means of age, gender, spherical refraction and axial length (p>0.05). Baseline choroidal thickness measurements of the study and control group showed no significant difference. Oral caffeine intake caused a significant reduction in choroidal thickness compared with baseline, at all three measurement points, (p<0.05). There were no significant changes in IOP and OPA measurements compared with the baseline values (p>0.05). The choroidal thickness still continued to decrease for at least 4h following caffeine intake; whereas, the difference between 1 and 4h was not statistically significant (p>0.05). However, choroidal thicknesses, IOP and OPA values of the control group revealed no significant difference at all points when comparing measurements at baseline with 1 and 4h after placebo intake (p>0.05).Conclusions: We found no significant change in IOP and OPA following oral 200mg caffeine intake, while CT significantly decreased, for at least 4h.
dc.identifier.doi10.3109/15569527.2015.1104330
dc.identifier.endpage286
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue4
dc.identifier.pmid26555634
dc.identifier.scopus2-s2.0-84946599795
dc.identifier.scopusqualityQ3
dc.identifier.startpage281
dc.identifier.urihttps://doi.org/10.3109/15569527.2015.1104330
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3811
dc.identifier.volume35
dc.identifier.wosWOS:000384429000004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofCutaneous And Ocular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectCaffeine; choroid; ocular blood flow
dc.titleAcute effects of caffeine on choroidal thickness and ocular pulse amplitude
dc.typeArticle

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