Evaluation of the serum C-reactive protein-albumin ratio and its relationship with disease severity IN alopecia areata: A prospective case-control study

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dc.contributor.authorKalayci, Bulent Nuri
dc.contributor.authorBalta, Ilknur
dc.date.accessioned2026-06-19T06:39:21Z
dc.date.available2026-06-19T06:39:21Z
dc.date.issued2022
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground Alopecia areata (AA) is an autoimmune and inflammatory disease characterized by localized or diffuse non-scarring hair loss. The serum C-reactive protein (CRP)/albumin ratio (CAR) is a novel inflammatory marker and a significant prognostic indicator in several diseases. Aim We aimed to explore CAR in AA patients and healthy controls and analyze the possible correlation between CAR and disease severity. Method The present study was conducted with 65 eligible AA patients and 65 age- and gender-matched healthy controls. Disease severity was analyzed based on the Severity of Alopecia Tool (SALT) score. The CAR score was calculated by dividing serum CRP by the albumin content in both patient and healthy control groups. Findings 56.9% of the patients were male and 43.1% were female, and the mean age was 31.93 +/- 9.67. The patient group' mean CAR level (0.42 +/- 0.3) was statistically higher than that of the healthy controls (0.07 +/- 0.04), (p < 0.05). There were positive correlations between disease severity, CAR (r = 0.65; p < 0.01), and CRP (r = 0.66; p < 0.01), while the correlation between disease severity and albumin was negative (r = -0.56; p < 0.01). In the receiver operating characteristic analysis conducted on disease severity, the area under the curve was 0.16 for albumin, 0.92 for CRP, and 0.95 for CAR. The optimum CAR for AA severity was 0.38 with 87% sensitivity and 92% specificity. Conclusion In the study, we determined that the CAR was higher in AA patients when compared to the control group, and the elevation was associated with disease severity. The present study findings demonstrated that alopecia areata was associated with systemic inflammation, and CAR is a useful inflammatory marker in AA patients.
dc.identifier.doi10.1111/jocd.15460
dc.identifier.endpage7199
dc.identifier.issn1473-2130
dc.identifier.issn1473-2165
dc.identifier.issue12
dc.identifier.orcid0000-0001-5838-8528
dc.identifier.orcid0000-0002-0909-589X
dc.identifier.pmid36225083
dc.identifier.scopus2-s2.0-85141418149
dc.identifier.scopusqualityQ1
dc.identifier.startpage7194
dc.identifier.urihttps://doi.org/10.1111/jocd.15460
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5558
dc.identifier.volume21
dc.identifier.wosWOS:000878242900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Cosmetic Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260612
dc.subjectAlbumin
dc.subjectAlopecia Areata
dc.subjectC-Reactive Protein
dc.subjectC-Reactive Protein-Albumin Ratio (Car)
dc.subjectInflammatory Marker
dc.titleEvaluation of the serum C-reactive protein-albumin ratio and its relationship with disease severity IN alopecia areata: A prospective case-control study
dc.typeArticle

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