Investigation of the Levels of Serum Amyloid A, YKL-40, and Pentraxin-3 in Patients with Familial Mediterranean Fever

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dc.authoridAtukeren, Pinar/0000-0001-8219-4205;
dc.contributor.authorCiftci, Sefa
dc.contributor.authorCelik, Huseyin Tugrul
dc.contributor.authorAtukeren, Pinar
dc.contributor.authorCiftci, Nurdan
dc.contributor.authorDeniz, Mustafa Saygin
dc.contributor.authorYavuz, Yasemin Coskun
dc.contributor.authorKazanci, Fatmanur Hacievliyagil
dc.date.accessioned2025-10-24T18:08:47Z
dc.date.available2025-10-24T18:08:47Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackgroundFamilial Mediterranean Fever (FMF) is an autosomal recessive form of recurrent episodes of fever and an autoinflammatory disease characterized by inflammation of the serous membranes. The clinical diagnosis is supported by the laboratory findings. This study investigated the relationship of Serum Amyloid A (SAA), YKL-40, and Pentraxin-3 (PTX-3) with the FMF disease. MethodsAbout 50 patients with FMF were enrolled in this study. Patients were divided into three groups according to disease severity score (mild, moderate, and severe). Thirty-seven healthy individuals were included as the control group. Serum SAA, YKL-40, and PTX-3 concentrations were measured using an ELISA kit. ResultsSerum SAA and YKL-40 levels of FMF patients were significantly higher than in the control (P < 0.001). PTX-3 levels were found to be higher in patients even though there was no significant difference (P = 0.113). Whereas the positive predictive value was 71.9% for cut-off point of SAA, the positive predictive value was 83.3% for cut-off point of YKL-40. Whereas a significant correlation was detected in SAA and PTX-3 with YKL-40 (respectively; P = 0.036, P < 0.001), there was no correlation between the PTX-3 with SAA (P = 0.219). ConclusionsYKL-40 can be used together with SAA to support the diagnosis of FMF and to monitor the severity of the disease. In this study, YKL-40 levels were examined for the first time in FMF patients and further studies are necessary using larger patient samples.
dc.description.sponsorshipTurgut Ozal University [1, 015-04-2014]
dc.description.sponsorshipFinancial support for this study was provided by Turgut Ozal University Research Coordinator (sequence no: 1, project no: 015-04-2014).
dc.identifier.doi10.1002/jcla.21997
dc.identifier.endpage1163
dc.identifier.issn0887-8013
dc.identifier.issn1098-2825
dc.identifier.issue6
dc.identifier.pmid27230955
dc.identifier.scopus2-s2.0-84971493158
dc.identifier.scopusqualityQ1
dc.identifier.startpage1158
dc.identifier.urihttps://doi.org/10.1002/jcla.21997
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3286
dc.identifier.volume30
dc.identifier.wosWOS:000386935200059
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal Of Clinical Laboratory Analysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectFamilial Mediterranean Fever; inflammation; PTX-3; Serum Amyloid A; YKL-40
dc.titleInvestigation of the Levels of Serum Amyloid A, YKL-40, and Pentraxin-3 in Patients with Familial Mediterranean Fever
dc.typeArticle

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