Increased Exhaled 8-Isoprostane and Interleukin-6 in Patients with Helicobacter pylori Infection

Basit Öğe Kaydı
dc.authoridBozkurt, Bulent/0000-0003-4764-3735|Karamanli, Harun/0000-0001-5453-1526|Kizilirmak, Deniz/0000-0001-9445-1598;
dc.contributor.authorYildirim, Zeki
dc.contributor.authorBozkurt, Bulent
dc.contributor.authorOzol, Duygu
dc.contributor.authorArmutcu, Ferah
dc.contributor.authorAkgedik, Recep
dc.contributor.authorKaramanli, Harun
dc.contributor.authorKizilirmak, Deniz
dc.date.accessioned2025-10-24T18:09:23Z
dc.date.available2025-10-24T18:09:23Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackgroundHelicobacter pylori (H. pylori) infection triggers both local inflammation, usually in gastric mucosa, and chronic systemic inflammation. It is assumed that this local and systemic inflammation is caused by extracellular products excreted by H. pylori. The aim of this study was to investigate the possible association between H. pylori infection and a local inflammatory response in the airway by using exhaled breath condensate technique. Materials and MethodsThis study includes 41 H. pylori seropositive patients who have gastric symptoms and 27 healthy control subjects. Pulmonary function tests (PFT), chest X ray, and physical examination were performed in all patients and interleukin-6 (IL-6), 8-isoprostane and nitrotyrosine levels were measured in exhaled breath condensate. ResultsLevels of IL-6 and 8-isoprostane in exhaled breath condensate (EBC) were significantly higher in H. pylori positive patients than control subjects (p < 0.05). Nitrotyrosine levels were also higher in H. pylori positive patients but the difference was not statistically significant. Both groups had similar leukocyte counts, C-reactive protein (CRP) levels and PFT parameters. ConclusionH. pylori infection causes an asymptomatic airway inflammation which can be detected by exhaled breath condensate. The clinical importance of this inflammation remains unclear.
dc.description.sponsorshipFatih University Foundation
dc.description.sponsorshipThis study was supported by Fatih University Foundation.
dc.identifier.doi10.1111/hel.12302
dc.identifier.endpage394
dc.identifier.issn1083-4389
dc.identifier.issn1523-5378
dc.identifier.issue5
dc.identifier.pmid27061444
dc.identifier.scopus2-s2.0-84986882197
dc.identifier.scopusqualityQ1
dc.identifier.startpage389
dc.identifier.urihttps://doi.org/10.1111/hel.12302
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3610
dc.identifier.volume21
dc.identifier.wosWOS:000384428100006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.ispartofHelicobacter
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectHelicobacter pylori; airway; inflammation; oxidative stress
dc.titleIncreased Exhaled 8-Isoprostane and Interleukin-6 in Patients with Helicobacter pylori Infection
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu