Effects of Ginkgo biloba extract on brain oxidative condition after cisplatin exposure

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dc.authoridGULEC PEKER, Emine Gulceri/0000-0001-7244-0281|ACAR KARAKURT, Meryem Dilek/0000-0002-2314-8126|AYYILDIZ, Mustafa/0000-0002-6594-3080|DANE, SENOL/0000-0001-5572-9454
dc.contributor.authorAydin, Duygu
dc.contributor.authorPeker, Emine G. G.
dc.contributor.authorKarakurt, Meryem D.
dc.contributor.authorGurel, Ayse
dc.contributor.authorAyyildiz, Mustafa
dc.contributor.authorCevher, Sule C.
dc.contributor.authorAgar, Erdal
dc.date.accessioned2025-10-24T18:10:31Z
dc.date.available2025-10-24T18:10:31Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurpose: The purpose of this study was to evaluate the efficacy of Ginkgo biloba extract (EGb 761) on oxidative events of brain in cisplatin-administrated rats. Methods: Rats were divided into four experimental groups: 1) control (n=6); 2) cisplatin (8 mg/kg, intraperitoneally one dose, n=6); 3) EGb 761 (100 mg/kg intraperitoneally for 15 days, n=6); and 4) cisplatin + EGb 761 (n=6). After drug administration, rats were sacrificed and brain tissues were removed. Nitric oxide (NO), malondialdehyde (MDA) and glutathione (GSH) levels were evaluated in brain tissues. Results: Single dose cisplatin administration significantly increased NO and GSH levels, but decreased MDA levels in brain tissue samples. EGb 761 treatment reversed the effects of cisplatin on NO and GSH levels, but did not affect the decreased MDA levels. Conclusion: Results of the study indicate that oxidative stress can be an important pathogenetic mechanism of cisplatin-induced neurotoxicity. EGb 761, an standardized extract of G. biloba leaves that has antioxidant properties, may improve the oxidative stress-related neurological side effects of cisplatin.
dc.identifier.endpageS105
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue6
dc.identifier.pmid27917801
dc.identifier.scopus2-s2.0-85047591986
dc.identifier.scopusqualityQ2
dc.identifier.startpageS100
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4229
dc.identifier.volume39
dc.identifier.wosWOS:000389725000021
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherCanadian Soc Clinical Investigation
dc.relation.ispartofClinical And Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectInduced Epileptiform Activity; Nitric-Oxide; Neurodegenerative Diseases; Adenosine-Deaminase; Xanthine-Oxidase; Oxygen Radicals; Ascorbic-Acid; Rats; Stress; Damage
dc.titleEffects of Ginkgo biloba extract on brain oxidative condition after cisplatin exposure
dc.typeArticle

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