Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity

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dc.authoridsahin, mustafa/0000-0002-4718-0083|Delibasi, Tuncay/0000-0002-5780-8209;
dc.contributor.authorYilmaz, H.
dc.contributor.authorUcan, B.
dc.contributor.authorSayki, M.
dc.contributor.authorUnsal, I.
dc.contributor.authorSahin, M.
dc.contributor.authorOzbek, M.
dc.contributor.authorDelibasi, T.
dc.date.accessioned2025-10-24T18:09:00Z
dc.date.available2025-10-24T18:09:00Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground: There is growing consensus in the literature that inflammation plays a central role in the pathophysiology of obesity and type 2 diabetes mellitus (T2DM) and cardiovascular complications. Neutrophil-to-lymphocyte ratio (NLR) provides a simple method for assessment of inflammatory status and it is a new, inexpensive marker. The aim of the present study was to investigate the predictive value of preprocedural (before the OGTT) NLR on development of type 2 diabetes (T2DM) in morbid obesity patients (MOP). Methods: 306 MOP (body mass index >= 40 kg/m(2)) and 95 normal weight patients with normal OGTT [ fasting plasma glucose (FPG) < 100 mg/dL. Two-hour glucose during OGTT < 140 mg/dL] were evaluated in this study. Results: The mean +/- SD NLR of MOP was significantly higher than that of patients with normal weight healthy patients (3.67 +/- 0.95 vs. 1.82 +/- 1.02, P < 0.001, respectively). In receiver operating characteristics curve analysis, NLR > 3.12 had 79.2% sensitivity and 64.9% specificity in predicting T2DM. Logistic regression analysis showed that elevated NLR (OR: 2.577, 95% CI: 1.363-4.872, P = 0.004) was an independent variable for predicting T2DM in MOP. Conclusions: MOP have higher NLR than healthy controls. High NLR is a powerful and independent predictor of T2DM in MOP. Elevated NLR levels are usually considered as an inflammatory marker. The results of this study suggested that inflammation plays a role in the pathogenesis of T2DM with MOP. (C) 2014 Diabetes India. Published by Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.dsx.2014.04.009
dc.identifier.endpage304
dc.identifier.issn1871-4021
dc.identifier.issn1878-0334
dc.identifier.issue4
dc.identifier.pmid25470646
dc.identifier.scopus2-s2.0-84988528110
dc.identifier.scopusqualityQ1
dc.identifier.startpage299
dc.identifier.urihttps://doi.org/10.1016/j.dsx.2014.04.009
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3414
dc.identifier.volume9
dc.identifier.wosWOS:000215401100019
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofDiabetes & Metabolic Syndrome-Clinical Research & Reviews
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectMorbid obesity; Neutrophil-to-lymphocyte ratio; Inflammation marker; Type 2 diabetes mellitus
dc.titleUsefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity
dc.typeArticle

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