Protective effect of curcumin on ovarian reserve in a rat ischemia model: an experimental study

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dc.contributor.authorEser, A.
dc.contributor.authorHizli, D.
dc.contributor.authorNamuslu, M.
dc.contributor.authorHaltas, H.
dc.contributor.authorKosus, N.
dc.contributor.authorKosus, A.
dc.contributor.authorKafali, H.
dc.date.accessioned2025-10-24T18:09:34Z
dc.date.available2025-10-24T18:09:34Z
dc.date.issued2017
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurpose of investigation: To determine the protective effect of curcumin on ovarian reserve in a rat ischemia model. Materials and Methods: Thirty female Albino rats were randomly divided into two groups by time of unilateral, left ovary ischemia/reperfusion (group 1: two-hour ischemia / two-hour reperfusion; group 2: four-hour ischemia / four-hour reperfusion). Each group was subdivided into three subgroups, sham, control, and curcumin (intraperitoneal curcumin (200 mg/kg) simultaneously with reperfusion). Histological grading of ischemic indices of paraffin-embedded ovarian tissue using hematoxylin and eosin (H&E), and anti-Mullerian hormone (AMH) levels by enzyme-linked immunosorbent assay (ELISA), were measured 40 days later. Results: No difference was found between groups 1 and 2 or among subgroups within either group for right and left ovary grades. AMH levels were significantly higher in the curcumin subgroup compared to sham and control within group 2 and in group 2 versus group 1 curcumin subgroups. Conclusion: Curcumin maintains and protects ovarian functions in an ischemia-reperfusion rat model.
dc.identifier.doi10.12891/ceog3235.2017
dc.identifier.endpage457
dc.identifier.issn0390-6663
dc.identifier.issue3
dc.identifier.pmid29949292
dc.identifier.scopus2-s2.0-85037119817
dc.identifier.scopusqualityQ4
dc.identifier.startpage453
dc.identifier.urihttps://doi.org/10.12891/ceog3235.2017
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3712
dc.identifier.volume44
dc.identifier.wosWOS:000401497300025
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherI R O G Canada, Inc
dc.relation.ispartofClinical And Experimental Obstetrics & Gynecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectCurcumin; Ovarian reserve; Rat-ischemia model; Ischemia-reperfusion; Anti-Mullerian hormone
dc.titleProtective effect of curcumin on ovarian reserve in a rat ischemia model: an experimental study
dc.typeArticle

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