The role of human Dectin-1 Y238X gene polymorphism in recurrent vulvovaginal candidiasis infections

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dc.authoridKaygusuz, Ikbal/0000-0002-5635-505X|acar, muradiye/0000-0003-4357-5229;
dc.contributor.authorUsluogullari, Betul
dc.contributor.authorGumus, Ilknur
dc.contributor.authorGunduz, Esra
dc.contributor.authorKaygusuz, Ikbal
dc.contributor.authorSimavli, Serap
dc.contributor.authorAcar, Muradiye
dc.contributor.authorOznur, Murat
dc.date.accessioned2025-10-24T18:08:50Z
dc.date.available2025-10-24T18:08:50Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractRecurrent vulvovaginal candidiasis (RVVC) is defined as having four or more symptomatic vulvovaginal candidiasis (VVC) attacks within a year. This study aimed to investigate whether Human Dectin-1 Y238X Gene Polymorphism plays a role in RVVC pathogenesis. In order to examine and explore this aim, an experimental study was undergone. The clinical study design was conducted with 50 women diagnosed with RVVC and had four or more symptomatic VVC attacks who were included in the experimental group; while 50 women who did not have previous RVVC history and diagnosis and did not have vaginal discharge and itching in the past year were included in the control group. Blood samples were collected from these patients and transferred to EDTA tubes, to investigate the Dectin-1 Y238X gene polymorphism, and stored at -80A degrees. When Dectin-1 genotypes were compared, there was no significant difference between the two groups (p = 0.452, p = 0.615, p = 0.275). History of familial RVVC was significantly higher in the experimental group (p = 0.001). When the multivariate analysis was used to evaluate factors that could determine RVVC frequency, history of familial RVVC was found to increase the frequency of RVVC attacks by 3.3 units. This study is the first-of-its-kind to investigate the correlation between Dectin-1 Y238X polymorphism, which has not been previously studied in the Turkish population, and RVVC. The result of this study suggests that there is no correlation between this polymorphism and RVVC.
dc.identifier.doi10.1007/s11033-014-3562-2
dc.identifier.endpage6768
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue10
dc.identifier.pmid25008994
dc.identifier.scopus2-s2.0-84919390603
dc.identifier.scopusqualityQ2
dc.identifier.startpage6763
dc.identifier.urihttps://doi.org/10.1007/s11033-014-3562-2
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3335
dc.identifier.volume41
dc.identifier.wosWOS:000342440000048
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMolecular Biology Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectHuman Dectin-1 Y238X gene mutation Recurrent vulvovaginal candidiasis; Gene polymorphism
dc.titleThe role of human Dectin-1 Y238X gene polymorphism in recurrent vulvovaginal candidiasis infections
dc.typeArticle

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