The protective role of thymoquinone in the prevention of gentamicin ototoxicity

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dc.authoridOzcan, Ibrahim/0000-0002-4359-2988|ALPER, AKCADAG/0009-0001-4212-6950;
dc.contributor.authorSagit, Mustafa
dc.contributor.authorKorkmaz, Ferhat
dc.contributor.authorGurgen, Seren Gulsen
dc.contributor.authorKaya, Mesut
dc.contributor.authorAkcadag, Alper
dc.contributor.authorOzcan, Ibrahim
dc.date.accessioned2025-10-24T18:08:58Z
dc.date.available2025-10-24T18:08:58Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: To investigate the potential protective effect of thymoquinone in gentamicin-induced ototoxicity through auditory brain stem responses (ABR) testing and histomorphological evaluation of the cochlea. Methods: This study was conducted on 48 adult female Sprague-Dawley rats that were randomized into 4 groups. Group 1 received intraperitoneal gentamicin; group 2 received intraperitoneal gentamicin plus corn oil solution; group 3 received intraperitoneal thymoquinone; and group 4 received intraperitoneal gentamicin plus thymoquinone. All groups received the drugs (once daily) in the above-mentioned protocols over 15 days. After conducting repeated ABR measurements, the rats were sacrificed, and their cochleae were isolated. Results: ABR thresholds were preserved in the gentamicin plus thymoquinone group when compared with the group receiving gentamicin alone. There were fewer TUNEL-positive cells and caspase-3 and caspase-9 expressions were weaker in the inner and outer hairy cells of the organ of Corti in the gentamicin plus thymoquinone group compared with the group receiving gentamicin alone. Conclusion: The ABR values and number of apoptotic cells did not significantly increase in the group receiving gentamicin plus thymoquinone when compared to the group receiving gentamicin alone. Again, the cochlear histomorphological findings were supportive of the auditory findings. In light of these findings, we conclude that gentamicin-induced ototoxicity may be prevented by thymoquinone use in rats. (C) 2014 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.amjoto.2014.07.002
dc.identifier.endpage609
dc.identifier.issn0196-0709
dc.identifier.issn1532-818X
dc.identifier.issue5
dc.identifier.pmid25087465
dc.identifier.scopus2-s2.0-84907733221
dc.identifier.scopusqualityQ1
dc.identifier.startpage603
dc.identifier.urihttps://doi.org/10.1016/j.amjoto.2014.07.002
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3379
dc.identifier.volume35
dc.identifier.wosWOS:000342119600011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherW B Saunders Co-Elsevier Inc
dc.relation.ispartofAmerican Journal Of Otolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectInduced Hearing-Loss; Guinea-Pig; Aminoglycoside Ototoxicity; Rat Cochlea; Hair-Cells; Toxicity; Injury; Mice
dc.titleThe protective role of thymoquinone in the prevention of gentamicin ototoxicity
dc.typeArticle

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