Increased levels of galectin-3 were associated with prediabetes and diabetes: new risk factor?

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dc.authoridDarcin, Tahir/0000-0001-5073-1790
dc.contributor.authorYilmaz, H.
dc.contributor.authorCakmak, M.
dc.contributor.authorInan, O.
dc.contributor.authorDarcin, T.
dc.contributor.authorAkcay, A.
dc.date.accessioned2025-10-24T18:08:53Z
dc.date.available2025-10-24T18:08:53Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurpose Galectin-3 (Gal-3) is a marker of cardiac fibrosis and predicts incident heart failure. Gal-3-deficient mice are resistant to multiple low-dose streptozotocin-induced diabetes. Recent experimental studies suggested an important role for Gal-3 in the regulation of adiposity, metaflammation and type 2 diabetes. This study aimed to examine the relationship between Gal-3 and newly diagnosed prediabetes and diabetes. Methods Gal-3 concentrations were measured in 118 participants and 56 age-and sex-matched healthy controls. All subjects underwent a 75-g oral glucose tolerance test and were stratified into normal, prediabetic, and diabetes mellitus subgroups. DM was defined as a plasma glucose level >= 126 mg/dL in the fasting state or >= 200 mg/dL in the second hour after glucose loading. Impaired fasting glucose was defined as an FPG level of 100-125 mg/dL, and impaired glucose tolerance was defined as a 2-h plasma glucose level of 140-199 mg/dL. Results Sixty-one patients had prediabetes (Group 1), 57 had diabetes (Group 2), and 56 had neither diabetes nor prediabetes (Group 3). Gal-3 levels correlated with FPG (r = 0.787, P < 0.01), 2hPG (r = 0.833, P < 0.01), CRP (r = 0.501, P < 0.01), and HOMA-IR (r = 0.518, P < 0.01). Gal-3 levels were higher in Group 2 than in Groups 1 and 3 [1,053.9 (358.1) and 744.1 (119.3) vs. 481.7 (175.4) pg/mL; P < 0.001]. Gal-3 is an independent predictor of diabetes in multivariate logistic analysis. In ROC analysis, a Gal-3 cutoff value of 803.55 pg/mL diagnoses diabetes with a sensitivity of 80.7 % and a specificity of 85.5 % (AUC = 0.912). Conclusions Gal-3 is a promising biomarker for detecting prediabetes and diabetes.
dc.identifier.doi10.1007/s40618-014-0222-2
dc.identifier.endpage533
dc.identifier.issn1720-8386
dc.identifier.issue5
dc.identifier.pmid25501605
dc.identifier.scopus2-s2.0-84928667342
dc.identifier.scopusqualityQ1
dc.identifier.startpage527
dc.identifier.urihttps://doi.org/10.1007/s40618-014-0222-2
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3362
dc.identifier.volume38
dc.identifier.wosWOS:000354403200006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal Of Endocrinological Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectGalectin-3; Prediabetes; Diabetes; Insulin resistance; Inflammation
dc.titleIncreased levels of galectin-3 were associated with prediabetes and diabetes: new risk factor?
dc.typeArticle

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