ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse

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dc.authoridTopcu, Vehap/0000-0001-6881-3284|YONEZAWA, Tomoko/0000-0002-3380-8298|Takigawa, Tomoyuki/0000-0003-3936-3071|Topcu, Vehap/0000-0001-7224-5697
dc.contributor.authorDemircan, Kadir
dc.contributor.authorYonezawa, Tomoko
dc.contributor.authorTakigawa, Tomoyuki
dc.contributor.authorTopcu, Vehap
dc.contributor.authorErdogan, Serpil
dc.contributor.authorUcar, Fatma
dc.contributor.authorArmutcu, Ferah
dc.date.accessioned2025-10-24T18:09:10Z
dc.date.available2025-10-24T18:09:10Z
dc.date.issued2013
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are involved in a variety of biological processes such as angiogenesis, cancer and arthritis. ADAMTSs appears to be responsible for the cleavage of proteoglycans in several tissues including brain and cartilage. Chondroitin sulfate proteoglycans (CSPGs) maintains the integrity of the brain extracellular matrix and major inhibitory contributors for glial scar and neural plasticity. The activity of aggrecanases in the central nervous system (CNS)has been reported. ADAMTSs are an enzyme degrading CSPGs in the brain. However, there is a little knowledge regarding ADAMTSs in the CNS. We investigated the expression levels of ADAMTSs mRNAs by RT-PCR after spinal cord injury in mouse. Transcripts encoding 4 of the 19 known ADAMTSs were evaluated in the mouse spinal cord following injury. ADAMTS1, -5 and -9 expression levels were found to be upregulated. No change was observed in ADAMTS4 expression. By means of immunohistochemistry, ADAMTSs were detected in the astrocytes implying its cellular source in SCI. Western blot analyses indicated that aggrecanase-generated proteoglycan fragments are produced after SCI. (c) 2013 Elsevier Ireland Ltd. All rights reserved.
dc.description.sponsorshipTurgut Ozal University; Okayama University Scientific Research Program; The Scientific and Technological Research Council of Turkey (TUBITAK) grant [SBAG 3501]; Japan Society of Promotion Science (JSPS); Takeda Science Foundation Post Doctoral Research Scholarship; Grants-in-Aid for Scientific Research [23390348, 23592164, 23390366, 24659590] Funding Source: KAKEN
dc.description.sponsorshipWe acknowledge the support of the Turgut Ozal University and Okayama University Scientific Research Program. K. Demircan is funded by the The Scientific and Technological Research Council of Turkey (TUBITAK) grant SBAG 3501. K.D. received Japan Society of Promotion Science (JSPS) and Takeda Science Foundation Post Doctoral Research Scholarship, respectively. We also thank Dr. Suneel Apte (Cleveland, pioneering scientist of ADAMTS) for their excellent mentoring, encouragement of junior scientists and technical help.
dc.identifier.doi10.1016/j.neulet.2013.02.064
dc.identifier.endpage30
dc.identifier.issn0304-3940
dc.identifier.pmid23562508
dc.identifier.scopus2-s2.0-84878377642
dc.identifier.scopusqualityQ2
dc.identifier.startpage25
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2013.02.064
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3477
dc.identifier.volume544
dc.identifier.wosWOS:000320632300006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofNeuroscience Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectADAMTS; Aggrecanase; Spinal cord injury; Astrocytes
dc.titleADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse
dc.typeArticle

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