Curcumin Attenuates Inflammation, Oxidative Stress, and Ultrastructural Damage Induced by Spinal Cord Ischemia-Reperfusion Injury in Rats

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dc.authoridSargon, Mustafa Fevzi/0000-0001-6360-6008
dc.contributor.authorGokce, Emre Cemal
dc.contributor.authorKahveci, Ramazan
dc.contributor.authorGokce, Aysun
dc.contributor.authorSargon, Mustafa Fevzi
dc.contributor.authorKisa, Ucler
dc.contributor.authorAksoy, Nurkan
dc.contributor.authorCemil, Berker
dc.date.accessioned2025-10-24T18:09:05Z
dc.date.available2025-10-24T18:09:05Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjectives: Curcumin is a molecule found in turmeric root that possesses anti-inflammatory and antioxidant properties and has been widely used to treat neurodegenerative diseases. We investigated whether curcumin stimulates the neurorepair process and improves locomotor function in a rat model of spinal cord ischemia-reperfusion injury. Methods: Thirty-two Wistar albino rats (190220 g) were randomly allocated into 4 groups of 8 rats each: 1 sham-operated group and 3 ischemia-reperfusion injury groups that received intraperitoneal injections of saline vehicle, methylprednisolone (MP, 30 mg/kg following induction of ischemia-reperfusion [IR] injury), or curcumin (200 mg/kg for 7 days before induction of IR injury). Spinal cord IR injury was induced by occlusion of the abdominal aorta for 30 minutes. After 24 hours of reperfusion, locomotor function was assessed using the Basso, Beattie, and Bresnahan scale. All animals were sacrificed. Spinal cord tissues were harvested to evaluate histopathological and ultrastructural alterations and to analyze levels of malondialdehyde, tumor necrosis factor-alpha, interleukin-1 beta, nitric oxide, and caspase-3, as well as enzyme activities of superoxide dismutase and glutathione peroxidase. Results: Intraperitoneal administration of curcumin significantly reduced inflammatory cytokine expression, attenuated oxidative stress and lipid peroxidation, prevented apoptosis, and increased antioxidant defense mechanism activity in comparison to treatment with MP or saline. Histopathological and ultrastructural abnormalities were significantly reduced in curcumin-treated rats compared to the MP-and saline-treated groups. Furthermore, curcumin significantly improved locomotor function. Conclusions: Curcumin treatment preserves neuronal viability against inflammation, oxidative stress, and apoptosis associated with ischemia-reperfusion injury. (C) 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.jstrokecerebrovasdis.2016.01.008
dc.identifier.endpage1207
dc.identifier.issn1052-3057
dc.identifier.issn1532-8511
dc.identifier.issue5
dc.identifier.pmid26935117
dc.identifier.scopus2-s2.0-84959253782
dc.identifier.scopusqualityQ1
dc.identifier.startpage1196
dc.identifier.urihttps://doi.org/10.1016/j.jstrokecerebrovasdis.2016.01.008
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3464
dc.identifier.volume25
dc.identifier.wosWOS:000375144200031
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofJournal Of Stroke & Cerebrovascular Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectCurcumin; spinal cord ischemia-reperfusion injury; inflammation; oxidative stress; lipid peroxidation
dc.titleCurcumin Attenuates Inflammation, Oxidative Stress, and Ultrastructural Damage Induced by Spinal Cord Ischemia-Reperfusion Injury in Rats
dc.typeArticle

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