Median and Ulnar Neuropathy Assessment in Parkinson's Disease regarding Symptom Severity and Asymmetry

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dc.authoridCakirbay, Hasim/0009-0008-4693-4112|Karaismailoglu, Eda/0000-0003-3085-7809|Yardimci, Nilgul/0000-0002-1602-1186
dc.contributor.authorYardimci, Nilgul
dc.contributor.authorCemeroglu, Ozlem
dc.contributor.authorOzturk, Eda
dc.contributor.authorGurlu, Gulsum
dc.contributor.authorSahin, Esra
dc.contributor.authorBozkurt, Saliha
dc.contributor.authorCengiz, Tugba
dc.date.accessioned2025-10-24T18:09:27Z
dc.date.available2025-10-24T18:09:27Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground. While increasing evidence suggests comorbidity of peripheral neuropathy (PNP) and Parkinson's disease (PD), the pathogenesis of PNP in PD is still a debate. The aim of this article is to search the core PD symptoms such as rigidity and tremor as contributing factors to mononeuropathy development while emphasizing each individual patient's asymmetric symptom severity. Methods. We studied 62 wrists and 62 elbows of 31 patients (mean age 66.48 +/- 10.67) and 64 wrists and 64 elbows of 32 age-gender matched healthy controls (mean age 62.03 +/- 10.40, p = 0.145). The Hoehn and Yahr disability scale and Unified Parkinson's Disease Rated Scale were used to determine the severity of the disease. Results. According to electrodiagnostic criteria, we confirmed median neuropathy in 16.12% (bilateral in two-thirds of the patients) and ulnar neuropathy in 3.22% of the PD group. While mean age (p = 0.003), age at PD onset (p = 0.019), and H&Y scores (p = 0.016) were significant, tremor and rigidity scores were not. The comparison of the mean indices of electrophysiologic parameters indicated subclinical median and ulnar nerve demyelination both at the wrist and at the elbow in the patient groups where a longer disease duration and mild tremor and rigidity scores are prominent, remarkably. Conclusion. A disease related peripheral neurodegeneration beyond symptom severity occurs in PD.
dc.identifier.doi10.1155/2016/4958068
dc.identifier.issn2090-8083
dc.identifier.issn2042-0080
dc.identifier.pmid27843673
dc.identifier.scopus2-s2.0-84994556277
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1155/2016/4958068
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3655
dc.identifier.volume2016
dc.identifier.wosWOS:000387424400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofParkinsons Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectCarpal-Tunnel-Syndrome; Tremor
dc.titleMedian and Ulnar Neuropathy Assessment in Parkinson's Disease regarding Symptom Severity and Asymmetry
dc.typeArticle

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