Gut satiety hormones and hyperemesis gravidarum

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dc.authoridKosus, Nermin/0000-0003-2390-9498
dc.contributor.authorKosus, Aydin
dc.contributor.authorKosus, Nermin
dc.contributor.authorUsluogullari, Betul
dc.contributor.authorHizli, Deniz
dc.contributor.authorNamuslu, Mehmet
dc.contributor.authorAyyildiz, Abdullah
dc.date.accessioned2025-10-24T18:08:48Z
dc.date.available2025-10-24T18:08:48Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractHyperemesis gravidarum (HG) is described as unexplained excessive nausea and vomiting during pregnancy. Some gut hormones that regulate appetite may have important role in etiopathogenesis of HG and weight changes during pregnancy. In this study, levels of gut satiety hormones were evaluated in pregnant women with HG. Methods This prospective case-control study was conducted in 30 women with HG and 30 healthy pregnant women without symptoms of HG. Fasting venous blood samples were taken from all subjects for measurement of plasma gut hormone levels; obestatin (pg/mL), peptide YY (PYY), pancreatic polypeptide (PP) and cholecystokinin (CCK). Results Plasma PYY and PP levels were significantly higher in HG group. The most important parameter in diagnosis of HG was plasma PP level. Simple use of PP level led to the diagnosis 91.1 % of HG cases correctly. The single most important parameter in the prediction of HG was also PP level. Conclusion Anorexigenic gut hormones might have important role in etiopathogenesis of hyperemesis gravidarum and weight changes during pregnancy.
dc.identifier.doi10.1007/s00404-015-3751-9
dc.identifier.endpage1230
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue6
dc.identifier.pmid25990478
dc.identifier.scopus2-s2.0-84944277748
dc.identifier.scopusqualityQ2
dc.identifier.startpage1225
dc.identifier.urihttps://doi.org/10.1007/s00404-015-3751-9
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3310
dc.identifier.volume292
dc.identifier.wosWOS:000363016100011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofArchives Of Gynecology And Obstetrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectEmesis; Gut hormone; Pregnancy; Weight change
dc.titleGut satiety hormones and hyperemesis gravidarum
dc.typeArticle

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