Serum and aqueous xanthine oxidase levels, and mRNA expression in anterior lens epithelial cells in pseudoexfoliation

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dc.authoridacar, muradiye/0000-0003-4357-5229|Simavli, Huseyin/0000-0003-1657-9099
dc.contributor.authorSimavli, Huseyin
dc.contributor.authorTosun, Mehmet
dc.contributor.authorBucak, Yasin Y.
dc.contributor.authorErdurmus, Mesut
dc.contributor.authorOcak, Zeynep
dc.contributor.authorOnder, Halil I.
dc.contributor.authorAcar, Muradiye
dc.date.accessioned2025-10-24T18:08:48Z
dc.date.available2025-10-24T18:08:48Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThe aim of this study was to determine serum and aqueous xanthine oxidase (XO) levels, and mRNA expression in anterior lens epithelial cells in pseudoexfoliation (PEX). In this prospective study, serum, aqueous and anterior lens capsules were taken from 21 patients with PEX and 23 normal subjects who had undergone routine cataract surgery. Serum and aqueous XO levels were analyzed using the colorimetric method. mRNA expression of XO in anterior lens epithelial cells was evaluated using reverse transcription polymerase chain reaction analysis. Serum XO levels (means +/- standard deviations) were 207.0 +/- 86.1 IU/mL and 240.6 +/- 114.1 IU/mL in the normal and PEX groups, respectively (p = 0.310). Aqueous XO levels (means +/- standard deviations) were 65.5 +/- 54.3 IU/mL in the normal group and 130.5 +/- 117.4 IU/mL in the PEX group (p = 0.028). There was a 2.9 fold decrease in mRNA expression in anterior lens epithelial cells of PEX, which is significantly lower than the normal group (p = 0.01). Higher aqueous XO levels lacking associated different serum XO suggests higher oxidative stress in the aqueous. Higher aqueous XO levels in PEX with decreased mRNA expression in anterior lens epithelial cells indicate possible overexpression of XO in other structures related to the aqueous.
dc.identifier.doi10.1007/s00417-015-3043-x
dc.identifier.endpage1167
dc.identifier.issn0721-832X
dc.identifier.issn1435-702X
dc.identifier.issue7
dc.identifier.pmid25957764
dc.identifier.scopus2-s2.0-84933178665
dc.identifier.scopusqualityQ1
dc.identifier.startpage1161
dc.identifier.urihttps://doi.org/10.1007/s00417-015-3043-x
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3317
dc.identifier.volume253
dc.identifier.wosWOS:000356948400021
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofGraefes Archive For Clinical And Experimental Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectPseudoexfoliation; Xanthine oxidase; Oxidative stress; Anterior lens capsule; Aqueous humor; mRNA expression
dc.titleSerum and aqueous xanthine oxidase levels, and mRNA expression in anterior lens epithelial cells in pseudoexfoliation
dc.typeArticle

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