Neutrophil-Lymphocyte Ratio (NLR) Could Be Better Predictor than C-reactive Protein (CRP) for Liver Fibrosis in Non-alcoholic Steatohepatitis(NASH)

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dc.authoridNadir, Isilay/0000-0002-6687-2894|YALCIN, Kadir Serkan/0000-0002-8028-1070
dc.contributor.authorYilmaz, Hakki
dc.contributor.authorYalcin, Kadir Serkan
dc.contributor.authorNamuslu, Mehmet
dc.contributor.authorCelik, Huseyin Tugrul
dc.contributor.authorSozen, Meral
dc.contributor.authorInan, Osman
dc.contributor.authorNadir, Isilay
dc.date.accessioned2025-10-24T18:10:29Z
dc.date.available2025-10-24T18:10:29Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground-Aim. Non-alcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease worldwide. The aims of this study were to assess Neutrophil-Lymphocyte Ratio (NLR) and C-reactive protein (CRP), and their association with liver histology in patients with non-alcoholic steatohepatitis (NASH), chronic hepatitis B (HBV), and hepatitis C (HCV). Material-Methods. We studied 38 consecutive patients with biopsy-proven NASH, 19 patients with HCV, 45 patients with HBV, and 35 healthy controls who were similar for age and gender. The stage of fibrosis was measured using a 6-point scale. Results. NLR was significantly higher in NASH patients compared to controls, HBV, and HCV patients (p<0.001, p<0.001, and p<0.001, respectively). NLR was positively associated with NAFLD activity scores (r=0.861, p<0.001). NLR was associated with hepatocyte ballooning degeneration (r=0.426, p=0.024), lobular inflammation(r=0.694, p<0.001), steatosis(r=0.498, p=0.007), and fibrosis stage(r=0.892, p<0.001) in NASH patients. Univariate and multivariate analyses showed that NLR was significantly associated with liver fibrosis and NAS (beta=0.631, p<0.001 for liver fibrosis; beta=0.753, p<0.001 for NAS in the multivariate model); however, CRP had no association with liver fibrosis and NAS. Conclusion. NLR is a promising and inexpensive inflammation marker that correlates with histological grade and fibrosis stage in NASH patients.
dc.identifier.endpage286
dc.identifier.issn0091-7370
dc.identifier.issn1550-8080
dc.identifier.issue3
dc.identifier.pmid26116591
dc.identifier.scopus2-s2.0-84934270600
dc.identifier.scopusqualityQ3
dc.identifier.startpage278
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4194
dc.identifier.volume45
dc.identifier.wosWOS:000356952100006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssoc Clinical Scientists
dc.relation.ispartofAnnals Of Clinical And Laboratory Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectNeutrophil-Lymphocyte Ratio; NASH; Inflammation; Fibrosis; Liver pathology
dc.titleNeutrophil-Lymphocyte Ratio (NLR) Could Be Better Predictor than C-reactive Protein (CRP) for Liver Fibrosis in Non-alcoholic Steatohepatitis(NASH)
dc.typeArticle

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