The effect of survivin gene promoter polymorphism on breast cancer

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dc.authoridSen, Meral/0000-0002-3424-624X|acar, muradiye/0000-0003-4357-5229|Bilgic, Celal Ismail/0000-0003-0434-8672;
dc.contributor.authorAltiparmak, Mehmet Deniz
dc.contributor.authorBilgic, Celal Ismail
dc.contributor.authorDener, Nuzhet Cenap
dc.contributor.authorGunduz, Esra
dc.contributor.authorYenidunya, Sibel
dc.contributor.authorAcar, Muradiye
dc.contributor.authorSen, Meral
dc.date.accessioned2025-10-24T18:09:47Z
dc.date.available2025-10-24T18:09:47Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBreast cancer is the most common malignant tumor in women and accounts for about 25% of all cancer diagnoses. Survivin is a member of the apoptosis inhibitor protein family of antiapoptotic proteins. In our study, we investigated one of those, the survivin gene promoter 31G/C polymorphism. Included in this study were 111 breast cancer patients who were operated on in our hospital and 101 healthy female subjects. Blood samples from the healthy subjects and paraffin-embedded tissue samples from the patients were used for DNA extraction and subsequent genetic analysis. PCR-RFLP was used for genotype analysis. We established the clinicopathologic characteristics of patients. No significant difference was found between survivin 31G/C promoter polymorphism of tumor characteristics and breast cancer. Between the control and breast cancer groups, survivin promoter polymorphism 31G/C differences were not significantly different (P = 0.058). The risk of developing cancer, having the relevant GC or CC genotype, is 1.413 times higher than those having genotype GG (95% confidence interval: 1.040 to 1.918). Carrying the C allele was statistically significant in terms of susceptibility to breast cancer. In conclusion, the use of survivin gene polymorphism as a risk factor in breast cancer is recommended based on the results of this study.
dc.description.sponsorshipTurgut Ozal university [P53011208_B]; Fatih university [P53011208_B]
dc.description.sponsorshipThis work is supported by the Scientific Research Fund of Turgut Ozal and Fatih universities under the project number P53011208_B.
dc.identifier.doi10.3906/biy-1405-78
dc.identifier.endpage866
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue6
dc.identifier.scopus2-s2.0-84911402008
dc.identifier.scopusqualityQ1
dc.identifier.startpage858
dc.identifier.trdizinid163184
dc.identifier.urihttps://doi.org/10.3906/biy-1405-78
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/163184
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3836
dc.identifier.volume38
dc.identifier.wosWOS:000345431100016
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectBreast cancer; apoptosis inhibitor protein; survivin; survivin gene promoter polymorphism; SNP
dc.titleThe effect of survivin gene promoter polymorphism on breast cancer
dc.typeArticle

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