The Investigation of a Disintegrin and Metalloproteinase with ThromboSpondin Motifs (ADAMTS) 1, 5 and 16 in Thoracic Aortic Aneurysms and Dissections

Basit Öğe Kaydı
dc.authoridAkpinar, Mehmet/0000-0002-4220-8390;
dc.contributor.authorGunes, Mahmut Fatih
dc.contributor.authorAkpinar, Mehmet Besir
dc.contributor.authorComertoglu, Ismail
dc.contributor.authorAkyol, Sumeyya
dc.contributor.authorDemircelik, Bora
dc.contributor.authorGurel, Ozgul Malcok
dc.contributor.authorAynekin, Busra
dc.date.accessioned2025-10-24T18:10:14Z
dc.date.available2025-10-24T18:10:14Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground: Disintegrin-like and Metalloproteinase with Thrombospondin Motifs (ADAMTS) proteins that are fundamentally located in the extracellular matrix (ECM) have critical roles on different cellular processes by altering the ECM architecture. It has been known that expression of some members of these proteinases increases in aneurismal and dissectional aortic tissue. The purpose of this study is to investigate ADAMTS1, 5, 16 and tissue inhibitors of metalloproteinases-1,-2 (TIMP-1,-2) levels in aortic tissue obtained from patients with thoracic aortic aneurysms and dissections and to achieve new insights about the function of ADAMTS family members. Methods: We investigated ADAMTS1, 5, and 16 expression in human thoracic aortic aneurysms (TAA) (n = 22), thoracic aortic dissections (TAD) (n = 12), and thoracic aortas from age-matched control organ donors (n = 6) (a total number of 34 cases and 6 controls). The expression levels of ADAMTS proteins were determined by Western blot technique using anti-ADAMTS1, ADAMTS5, ADAMTS16, TIMP-1 and TIMP-2 antibodies. Results: ADAMTS1, 5, and 16 protein expressions were significantly higher in thoracic aortic aneurysm and dissection tissues compared to control aortic tissues. Furthermore, TIMP-1 protein levels decreased in TAA and TAD tissues, TIMP-2 did not change. Conclusions: Under the light of our findings, increased expression of ADAMTS1, 5, and 16 proteins may promote deceleration in thoracic aortic aneurysm progression. This is the first study that demonstrates ADAMTS5 and ADAMTS16 proteolytic activity in aneurysm and dissection.
dc.identifier.doi10.7754/Clin.Lab.2015.150730
dc.identifier.endpage433
dc.identifier.issn1433-6510
dc.identifier.issue3
dc.identifier.pmid27156333
dc.identifier.scopus2-s2.0-84969268039
dc.identifier.scopusqualityQ3
dc.identifier.startpage425
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2015.150730
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4057
dc.identifier.volume62
dc.identifier.wosWOS:000372668900022
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherClin Lab Publ
dc.relation.ispartofClinical Laboratory
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectdissection; ADAMTS5; ADAMTS16; TIMP-1; thoracic aorta aneurysm
dc.titleThe Investigation of a Disintegrin and Metalloproteinase with ThromboSpondin Motifs (ADAMTS) 1, 5 and 16 in Thoracic Aortic Aneurysms and Dissections
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu