An Experimental Comparison of the Effects of Propolis, Curcumin, and Methylprednisolone on Crush Injuries of the Sciatic Nerve

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dc.authoridcemil, berker/0000-0001-9192-6674|Sargon, Mustafa Fevzi/0000-0001-6360-6008|KOC, EMINE RABIA/0000-0002-0264-7284;
dc.contributor.authorYuce, Serdar
dc.contributor.authorGokce, Emre Cemal
dc.contributor.authorIsikdemir, Ahmet
dc.contributor.authorKoc, Emine Rabia
dc.contributor.authorCemil, Duran Berker
dc.contributor.authorGokce, Aysun
dc.contributor.authorSargon, Mustafa F.
dc.date.accessioned2025-10-24T18:09:21Z
dc.date.available2025-10-24T18:09:21Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground: Propolis and curcumin have antioxidant, anti-inflammatory, immunomodulatory, and neuroprotective features. The goal of this study was to determine the effects of propolis and curcumin on nerve healing in rat sciatic nerve crush injuries and to compare these effects with results obtained using steroid treatment. Methods: In the sham group, the right sciatic nerves of rats were dissected and exposed, and the skin was closed without any additional manipulation. In the control group (group C), after the right sciatic nerves of rats were exposed, crush damage was inflicted using a surgical clamp. In the control-methylprednisolone group, crush injuries were inflicted on sciatic nerves as in group C. After injury, 1-mg/kg methylprednisolone was administered daily for 6 days and was then tapered for 4 days. In the curcumin group, crush injuries were inflicted on sciatic nerves as in group C. Then, 100-mg/kg curcumin was given every day. In the propolis group, crush injuries were inf licted on sciatic nerves as in group C. Then, 200-mg/kg propolis was given every day. Rats were evaluated after 28 days using functional (walking track analysis and electrophysiological measurements), histomorphometric, electron microscopic, and muscle weight measurements. Results: Compared to the control groups, the curcumin and propolis groups had better functional (walking track analysis and electrophysiological) results after experimental peripheral nerve crush injury. Conclusions: Curcumin and propolis, 2 traditional drugs, had a positive effect on nerve crush injuries. We are convinced that they can be used to support routine treatment in such nerve injuries.
dc.description.sponsorshipoffice of scientific research projects of Turgut Ozal University
dc.description.sponsorshipThis study was supported by the office of scientific research projects of Turgut Ozal University.
dc.identifier.doi10.1097/SAP.0000000000000026
dc.identifier.endpage692
dc.identifier.issn0148-7043
dc.identifier.issn1536-3708
dc.identifier.issue6
dc.identifier.pmid24317243
dc.identifier.scopus2-s2.0-84929948428
dc.identifier.scopusqualityQ2
dc.identifier.startpage684
dc.identifier.urihttps://doi.org/10.1097/SAP.0000000000000026
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3582
dc.identifier.volume74
dc.identifier.wosWOS:000354888000011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofAnnals Of Plastic Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectcrush injury of nerve; curcumin; propolis; methylprednisolone
dc.titleAn Experimental Comparison of the Effects of Propolis, Curcumin, and Methylprednisolone on Crush Injuries of the Sciatic Nerve
dc.title.alternativeAn experimental comparison of the effects of propolis, curcumin, and methylprednisolone on crush injuries of the sciatic nerve
dc.typeArticle

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