Effects of the etonogestrel contraceptive implant (Implanon®) on bone metabolism during lactation: a prospective study

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dc.contributor.authorDuvan, Candan Iltemir
dc.contributor.authorOnaran, Yuksel
dc.contributor.authorKeskin, Esra Aktepe
dc.contributor.authorYuce, Ebru
dc.contributor.authorYanik, Burcu
dc.contributor.authorKafali, Hasan
dc.contributor.authorTurhan, Nilgun Ozturk
dc.date.accessioned2025-10-24T18:09:24Z
dc.date.available2025-10-24T18:09:24Z
dc.date.issued2017
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAim To evaluate the effects of the etonogestrel contraceptive implant (Implanon (R)) on bone metabolism in lactating women using markers for bone formation and resorption. Study design This single-centre, prospective cohort study was conducted in Turgut Ozal University Medical Faculty Obstetrics and Gynecology Department with healthy lactating women aged between 24 and 38 years to compare the effect on bone metabolism of 6 months' use of either the implant or a non-hormonal contraceptive method. The study group (n=25) used an implant and the control group (n=25) used a non-hormonal contraceptive intrauterine device inserted 40 days' postpartum. Bone metabolism differences at the time of insertion and after 6 months were assessed quantitatively by biochemical analysis of serum and urine samples. Results At baseline, serum levels of bone metabolism parameters were similar for the two groups. In the implant group, serum alkaline phosphatase (ALP) levels decreased (p=0.004) and total protein levels increased (p=0.045) at 6 months. In the control group, serum levels of bone metabolism parameters did not change at 6 months compared to baseline. However, serum levels of phosphorus (p=0.013) and ALP (p=0.003) decreased at 6 months compared to baseline. Conclusion Six months' postpartum use of Implanon was found to have no deleterious impact on bone turnover in healthy lactating women.
dc.identifier.doi10.1136/jfprhc-2015-101375
dc.identifier.endpage117
dc.identifier.issn1471-1893
dc.identifier.issn2045-2098
dc.identifier.issue2
dc.identifier.pmid27908964
dc.identifier.scopus2-s2.0-85019884648
dc.identifier.scopusqualityN/A
dc.identifier.startpage113
dc.identifier.urihttps://doi.org/10.1136/jfprhc-2015-101375
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3627
dc.identifier.volume43
dc.identifier.wosWOS:000404162200008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmj Publishing Group
dc.relation.ispartofJournal Of Family Planning And Reproductive Health Care
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectMineral Density; Turnover; Markers; Women
dc.titleEffects of the etonogestrel contraceptive implant (Implanon®) on bone metabolism during lactation: a prospective study
dc.typeArticle

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