Assessment of fetal antioxidant and oxidant status during different anesthesia techniques for elective cesarean sections

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dc.authoridBicer, Cemile/0000-0001-7937-4475|kaya, ahmet/0000-0002-8751-5298;
dc.contributor.authorKarabayirli, Safinaz
dc.contributor.authorKeskin, Esra Aktepe
dc.contributor.authorKaya, Ahmet
dc.contributor.authorKoca, Cemile
dc.contributor.authorErel, Ozcan
dc.contributor.authorDemircioglu, Ruveyda Irem
dc.contributor.authorMuslu, Bunyamin
dc.date.accessioned2025-10-24T18:09:57Z
dc.date.available2025-10-24T18:09:57Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground: We aimed to investigate the effects of general, spinal and epidural anesthesia on fetal total antioxidant status (TAS) and total oxidant status (TOS), and oxidative stress index (OSI) during elective cesarean section in this study. Materials and Methods: Forty-seven parturients scheduled for elective cesarean section were randomly allocated into three groups: Group spinal (n = 15), group epidural (n = 17), and group general (n = 15), This prospective randomized study was performed in Faculty of Medicine, Turgut Ozal University, Turkey. After the baby was delivered; TAS, TOS levels, and arterial blood gases parameters were analyzed in an umbilical arterial blood sample. OSI values are calculated by a ratio of TOS to the TAS. Results: The levels of TAS and TOS in umbilical arterial blood sample were not statistically different among three. However, OSI values were significantly different among the three groups (P = 0.042). Median OSI values is 24 (interquartile range [IQR], 2-37) in group spinal, 19 (IQR, 4-44) in group epidural, and 8 (IQR, 4-36) in group general. There was no significant difference in OSI values in the comparison of group spinal with group general and group epidural, but it was significantly lower in group general when compared with group epidural with Bonferroni correction (P = 0.017). Umbilical cord arterial blood gas values (pH, PaCO2 , PaO2 , SaO(2) , HCO3 , and CtO(2) ), glucose, lactate, and hemoglobin levels were similar in three groups. Conclusion: General anesthesia may be more favorable than epidural in those undergoing cesarean section when fetal oxidative status gains importance.
dc.description.sponsorshipClinical Research Ethics Committee of the Fatih University [B 30 2 FTH 0 20 00 00/2481]
dc.description.sponsorshipClinical Research Ethics Committee of the Fatih University, research project number; B 30 2 FTH 0 20 00 00/2481.
dc.identifier.doi10.4103/1735-1995.168373
dc.identifier.endpage744
dc.identifier.issn1735-1995
dc.identifier.issn1735-7136
dc.identifier.issue8
dc.identifier.pmid26664420
dc.identifier.scopus2-s2.0-84944742218
dc.identifier.scopusqualityQ2
dc.identifier.startpage739
dc.identifier.urihttps://doi.org/10.4103/1735-1995.168373
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3895
dc.identifier.volume20
dc.identifier.wosWOS:000364062100004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMedknow Publications & Media Pvt Ltd
dc.relation.ispartofJournal Of Research In Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectAnesthesia; cesarean section; oxidative stress
dc.titleAssessment of fetal antioxidant and oxidant status during different anesthesia techniques for elective cesarean sections
dc.typeArticle

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