Is There Any Relationship between Plasma Pentraxin 3 Levels and Gestational Diabetes Mellitus?

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dc.authoridKaygusuz, Ikbal/0000-0002-5635-505X;
dc.contributor.authorYildirim, Melahat
dc.contributor.authorSimavli, Serap Aynur
dc.contributor.authorDerbent, Aysel Uysal
dc.contributor.authorKaygusuz, Ikbal
dc.contributor.authorUysal, Sema
dc.date.accessioned2025-10-24T18:09:29Z
dc.date.available2025-10-24T18:09:29Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground: Pentraxin 3 (PTX3) is a novel vascular inflammatory marker which increases in vascular events such as diabetes mellitus. The aim of this study was to investigate the relationship between serum PTX3 levels and gestational diabetes mellitus (GDM). Methods: This prospective observational study was comprised of 88 pregnant women with singleton pregnancies. The subjects were classified into 3 groups according to their response to a 50-gram glucose challenge test (GCT) and a 100-gram oral glucose tolerance test: control group (n = 28), impaired glucose tolerance group (n = 30), and GDM group (n = 30). Serum PTX3 levels were measured to examine the relationship between GDM and GCT values. Results: Significant differences in PTX3 levels were observed among the 3 groups in the sample (F = 7.598; p = 0.001). The mean PTX3 value was found to be significantly higher in the GDM group (3.17 +/- 1.16 ng/ml) than in the control group (2.20 +/- 0.83 ng/ml; p = 0.001). A significant positive correlation between PTX3 and GCT values was detected (r = 0.289; p = 0.008). Conclusion: Maternal serum PTX3 levels were found to be significantly related to high blood glucose levels. This may be an indicator of vascular pathology in GDM around the time of an oral glucose tolerance test. (C) 2015 S. Karger AG, Basel
dc.identifier.doi10.1159/000373889
dc.identifier.endpage227
dc.identifier.issn0378-7346
dc.identifier.issn1423-002X
dc.identifier.issue4
dc.identifier.pmid25722060
dc.identifier.scopus2-s2.0-84951573435
dc.identifier.scopusqualityQ2
dc.identifier.startpage223
dc.identifier.urihttps://doi.org/10.1159/000373889
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3668
dc.identifier.volume80
dc.identifier.wosWOS:000366743700002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofGynecologic And Obstetric Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectPentraxin 3; Gestational diabetes mellitus; Vascular inflammation; Pregnancy; Inflammation
dc.titleIs There Any Relationship between Plasma Pentraxin 3 Levels and Gestational Diabetes Mellitus?
dc.typeArticle

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