Possible role of antioxidants and nitric oxide inhibitors against carbon monoxide poisoning: Having a clear conscience because of their potential benefits

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dc.contributor.authorAkyol, Sumeyya
dc.contributor.authorYuksel, Sevda
dc.contributor.authorPehlivan, Sultan
dc.contributor.authorErdemli, Haci Kemal
dc.contributor.authorGulec, Mehmet Akif
dc.contributor.authorAdam, Bahattin
dc.contributor.authorAkyol, Omer
dc.date.accessioned2025-10-24T18:09:06Z
dc.date.available2025-10-24T18:09:06Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractCarbon monoxide poisoning is one of the important emergency situations manifested by primarily acute and chronic anoxic central nervous system (CNS) injuries and other organ damages. Current descriptions and therapeutic approaches have been focused on the anoxic pathophysiology. However, this point of view incompletely explains some of the outcomes and needs to be investigated extensively. Considering this, we propose that reactive oxygen species (ROS) including especially nitric oxide (NO) are likely to be a key concept to understand the emergency related to CO poisoning and to discover new therapeutic modalities in CO toxicity. If we consider the hypothesis that ROS is involved greatly in acute and chronic toxic effects of CO on CNS and some other vital organs such as heart, it follows that the antioxidant and anti-NO therapies might give the clinicians more opportunities to prevent deep CNS injury. In support of this, we review the subject in essence and summarize clinical and experimental studies that support a key role of ROS in the explanation of pathophysiology of CO toxicity as well as new treatment modalities after CO poisoning. (C) 2016 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.mehy.2016.04.015
dc.identifier.endpage6
dc.identifier.issn0306-9877
dc.identifier.issn1532-2777
dc.identifier.pmid27241244
dc.identifier.scopus2-s2.0-84963860113
dc.identifier.scopusqualityQ1
dc.identifier.startpage3
dc.identifier.urihttps://doi.org/10.1016/j.mehy.2016.04.015
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3469
dc.identifier.volume92
dc.identifier.wosWOS:000378182600002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherChurchill Livingstone
dc.relation.ispartofMedical Hypotheses
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectCarbon monoxide poisoning; Anoxia; Injury; Reactive oxygen species; Nitric oxide; Antioxidant therapy
dc.titlePossible role of antioxidants and nitric oxide inhibitors against carbon monoxide poisoning: Having a clear conscience because of their potential benefits
dc.typeArticle

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