Relationship between cytosine-adenine repeat polymorphism of ADAMTS9 gene and clinical and radiologic severity of knee osteoarthritis

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dc.authoridacar, muradiye/0000-0003-4357-5229|Orhan, Kevser/0000-0001-8639-751X|Cakirbay, Hasim/0009-0008-4693-4112
dc.contributor.authorGok, Kevser
dc.contributor.authorCemeroglu, Ozlem
dc.contributor.authorCakirbay, Hasim
dc.contributor.authorGunduz, Esra
dc.contributor.authorAcar, Muradiye
dc.contributor.authorCetin, Elif Nihan
dc.contributor.authorGunduz, Mehmet
dc.date.accessioned2025-10-24T18:09:22Z
dc.date.available2025-10-24T18:09:22Z
dc.date.issued2018
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjectiveThe aim of this study is to determine the role of cytosine-adenine (CA) micro-satellite repeat sequence of ADAMTS9 gene on the development and progression of osteoarthritis (OA). MethodsA total of 110 participants, including those with primary knee OA and healthy controls were enrolled in the study. Patients were stratified into two groups using the Kellgren-Lawrence staging (K-L staging) as group 1 for controls and mild OA and group 2 for moderate and severe OA. Genetic analyses were performed to determine the CA repeat length in ADAMTS9 gene. ResultsTwenty CA repeats were found to be statistically significant for differentiating groups 1 and 2 (P = 0.020). Age was the most significant risk factor involved, followed by 20 CA repeats and body mass index (P < 0.05). CA repeat length of 20 showed a 6.1-fold increase in probability for having OA at stage 3 or 4 compared to those of CA repeat length of < 20 (P = 0.004). In conclusion, the CA repeat length of 20 has a six-fold increase in probability for having severe OA. ConclusionADAMTS9 gene CA repeat polymorphism may be used to determine the prognosis for OA radiologic progression. Being the first in the literature reporting the CA repeat in the promotor region of ADAMTS9 gene in patients with OA, our study could be highlighted further in future research with larger sample size.
dc.identifier.doi10.1111/1756-185X.12849
dc.identifier.endpage827
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue4
dc.identifier.pmid27230574
dc.identifier.scopus2-s2.0-84971290188
dc.identifier.scopusqualityQ3
dc.identifier.startpage821
dc.identifier.urihttps://doi.org/10.1111/1756-185X.12849
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3602
dc.identifier.volume21
dc.identifier.wosWOS:000429000500006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofInternational Journal Of Rheumatic Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectADAMTS9 gene; cytosine-adenine repeat; osteoarthritis; polymorphism
dc.titleRelationship between cytosine-adenine repeat polymorphism of ADAMTS9 gene and clinical and radiologic severity of knee osteoarthritis
dc.typeArticle

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