Effects of quercetin on kidney injury induced by doxorubicin

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dc.authoridyagmurca, murat/0000-0001-9774-8151;
dc.contributor.authorYagmurca, M.
dc.contributor.authorYasar, Z.
dc.contributor.authorBas, O.
dc.date.accessioned2025-10-24T18:09:57Z
dc.date.available2025-10-24T18:09:57Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractOBJECTIVES: The anthracycline antitumor drug doxorubicine causes severe nephrotoxicity in a variety of experimental animals and may be nephrotoxic to humans. The aim of present study was to determine the protective effects of quercetin against doxorubicin-induced kidney injury with light microscopy. METHODS: Forty male Wistar albino rats were divided into four groups: control, doxorubicin, doxorubicin + quercetin and quercetin. A single dose of 20 mg/kg/i.p. doxorubicin was used to induce injury. Quercetin was administrated orally against doxorubicin toxicity. The kidneys were examined under light microscopy after H&E (hematoxylin-eosin) staining and the changes were scored. RESULTS: Significant tissue injury was observed in doxorubicin-administered group. Among these injuries, renal tubular dilatation, tubular vacuolar changes, glomerular vacuolization, decrease in bowman space, bowman capsule thickening, and interstitial infiltration were evident. However, the injury induced by doxorubicin was attenuated with quercetin administration. DISCUSSION: Quercetin decreased doxorubicin-induced kidney damage (Tab. 1, Fig. 4, Ref 27). Text in PDF www.elis.sk.
dc.description.sponsorshipAfyon Kocatepe University Scientific Research Projects Coordination Unit [08.TIP.01]
dc.description.sponsorshipThis study was supported by Afyon Kocatepe University Scientific Research Projects Coordination Unit (Project Number: 08.TIP.01).
dc.identifier.doi10.4149/BLL_2015_092
dc.identifier.endpage489
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue8
dc.identifier.pmid26350088
dc.identifier.scopus2-s2.0-84962331869
dc.identifier.scopusqualityQ2
dc.identifier.startpage486
dc.identifier.urihttps://doi.org/10.4149/BLL_2015_092
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3899
dc.identifier.volume116
dc.identifier.wosWOS:000361083000006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univ
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectdoxorubicin; quercetin; nephrotoxicity; rat
dc.titleEffects of quercetin on kidney injury induced by doxorubicin
dc.typeArticle

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