Assessment of the efficacy of Ankaferd blood stopper on the prevention of postoperative pericardial adhesions

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dc.contributor.authorNazli, Yunus
dc.contributor.authorColak, Necmettin
dc.contributor.authorAlpay, Mehmet Fatih
dc.contributor.authorHaltas, Hacer
dc.contributor.authorAksoy, Omer Nuri
dc.contributor.authorAkkaya, Ismail Olgun
dc.contributor.authorCakir, Omer
dc.date.accessioned2025-10-24T18:10:12Z
dc.date.available2025-10-24T18:10:12Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjectives: Ankaferd has been used as a blood-stopping agent and it may also have an anti-inflammatory effect. We investigated the efficacy of Ankaferd in preventing postoperative pericardial adhesions in an experimental rabbit model. Methods: Sixteen New Zealand white rabbits were used and categorised into two groups: an Ankaferd and a control group. The Ankaferd group of rabbits was treated with a sponge impregnated with Ankaferd solution, which was applied over the abraded epicardium. A sponge impregnated with 0.9% isotonic NaCl solution was applied to the control group using the same protocol. Scores for adhesion and visibility of coronary vessels were graded by macroscopic examination, and pericardial tissues were analysed microscopically in terms of inflammation and fibrosis. Results: In the Ankaferd group, the adhesion scores were significantly higher than in the control group (p = 0.007). When the groups were compared according to the prevalence of fibrosis and degree of inflammation, the Ankaferd group was found to be statistically significantly different from the control group in terms of prevalence of fibrosis (p = 0.028). Conclusion: Topical application of Ankaferd to prevent postoperative pericardial adhesions increased adhesion and fibrosis scores.
dc.description.sponsorshipScientific Research Fund of Fatih University
dc.description.sponsorshipThis study was supported by the Scientific Research Fund of Fatih University.
dc.identifier.doi10.5830/CVJA-2014-011
dc.identifier.endpage+
dc.identifier.issn1995-1892
dc.identifier.issn1680-0745
dc.identifier.issue3
dc.identifier.pmid24633237
dc.identifier.scopus2-s2.0-84905020353
dc.identifier.scopusqualityQ3
dc.identifier.startpage100
dc.identifier.urihttps://doi.org/10.5830/CVJA-2014-011
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4042
dc.identifier.volume25
dc.identifier.wosWOS:000343278400003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherClinics Cardive Publ Pty Ltd
dc.relation.ispartofCardiovascular Journal Of Africa
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectcardiac operation; Ankaferd; pericardial adhesion
dc.titleAssessment of the efficacy of Ankaferd blood stopper on the prevention of postoperative pericardial adhesions
dc.typeArticle

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