The relationship between postmenopausal women's sclerostin levels and their bone density, age, body mass index, hormonal status, and smoking and consumption of coffee and dairy products

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dc.authoridKalem, Ziya/0000-0002-5435-2074|akgun, nilufer/0000-0003-0414-9470|NAMLI KALEM, MUBERRA/0000-0002-2316-5495;
dc.contributor.authorKalem, Muberra Namli
dc.contributor.authorKalem, Ziya
dc.contributor.authorAkgun, Nilufer
dc.contributor.authorBakirarar, Batuhan
dc.date.accessioned2025-10-24T18:08:48Z
dc.date.available2025-10-24T18:08:48Z
dc.date.issued2017
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractTo investigate the relationship between postmenopausal women's sclerostin levels and bone density and the factors that may affect this relationship. 135 postmenopausal patients' ages, BMIs, hormonal statuses, BMD values, and smoking, and consumption of coffee and dairy products were compared with their sclerostin levels. No statistical relationship was found between sclerostin level and age in the group with osteoporosis (p = 0.204, r = -0.305). There was a positive, high-level relationship between sclerostin levels and BMI in the osteoporosis group and it was found to be statistically significant (p < 0.001, r = 0.786). No statistical relationship was found between sclerostin level and age in the non-osteoporosis group with (p = 0.496, r = -0.88). There was a positive, moderate relationship between sclerostin levels and BMI in the non-osteoporosis group and it was found to be statistically significant (p < 0.001, r = 0.505). No statistically significant relationship could be found between sclerostin levels and vitamin D (p = 0.723), PTH (p = 0.112), FSH (p = 0.795), E-2 (p = 0.627), TSH (p = 0.517), T-3 (p = 0.788), and T-4 (p = 0.664) blood levels. No significant difference was found among the groups formed by smoking, consumption of coffee and milk, and dairy products, either (p = 0.405; p = 0.626; p = 0.234, respectively). It was monitored that sclerostin's negative effect observed on BMD scores was independent from age; however, it had a positive correlation with BMI. As blood sclerostin levels increase, bone mineral density decreases. This negative effect of sclerostin on bone density increases as BMI increases, too. Effects of sclerostin levels on bone density are independent from age, and they are not affect by levels of vitamin D: PTH, FSH, E-2 and thyroid hormones, and daily activities, such as smoking and consumption of coffee and milk and dairy products, either.
dc.identifier.doi10.1007/s00404-017-4288-x
dc.identifier.endpage793
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue3
dc.identifier.pmid28138749
dc.identifier.scopus2-s2.0-85010976803
dc.identifier.scopusqualityQ2
dc.identifier.startpage785
dc.identifier.urihttps://doi.org/10.1007/s00404-017-4288-x
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3312
dc.identifier.volume295
dc.identifier.wosWOS:000395012300028
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofArchives Of Gynecology And Obstetrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectSclerostin; Body mass index; Bone mineral density; Smoking; Coffee; Dairy products
dc.titleThe relationship between postmenopausal women's sclerostin levels and their bone density, age, body mass index, hormonal status, and smoking and consumption of coffee and dairy products
dc.title.alternativeThe relationship between postmenopausal women’s sclerostin levels and their bone density, age, body mass index, hormonal status, and smoking and consumption of coffee and dairy products
dc.typeArticle

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