Sinovac vaccination and the course of COVID-19 disease in hospitalized patients in Turkey
Yükleniyor...
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
King Faisal Specialist Hospital and Research Centre
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
BACKGROUND: The Alpha variant of SARS-CoV-2 has a higher transmission rate than the first variant identified. The efficacy of vaccines is affected by the characteristics of SARS-CoV-2 variants. OBJECTIVE: Investigate the relationship of vaccination and virus variant on the course of the disease in patients who were hospitalized with a diagnosis of COVID-19. DESIGN: Retrospective, cohort study SETTING: Tertiary health institution PATIENTS AND METHODS: The study included patients older than the age of 18 years who were hospitalized in a COVID-19 service or the intensive care unit with a diagnosis of COVID-19 between 1 January 2021 and 30 April 2021. Demographic characteristics, vaccination and the Alpha virus variant status, comorbidities, and information about hospitalization were obtained from the hospital automation system and patient files. MAIN OUTCOME MEASURES: Vaccination rate and relationship with course of disease. SAMPLE SIZE: 608 RESULTS: Most of the patients (n=482, 79.3%) were admitted to the COVID-19 service. More of the COVID-19 service patients had the Alpha variant than the patients admitted to ICU (P<.009). The Alpha variant was also more common in younger patients (P<.001). There was no relationship between the Alpha virus and comorbid diseases such as diabetes mellitus and hypertension. Mortality was lower in the patients who had received a second dose of the Sinovac vaccine (P=.004) compared with unvaccinated patients. CONCLUSION: Although the Alpha variant spreads faster, it has a milder course. If only the Sinovac vaccine is available, we recommend that the two doses of the Sinovac vaccine be administered. LIMITATIONS: Our study is single-center and did not include pregnant and pediatric patients. CONFLICT OF INTEREST: None.
Açıklama
Received30 October 2021, Accepted16 December 2021, Published online2 June 2022.
Copyright © 2022, Annals of Saudi Medicine, Saudi Arabia. This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND). The details of which can be accessed at http://creativecommons. org/licenses/by-nc-nd/4.0/
Delen, Leman Acuna, Department of Anesthesiology and Reanimation, Malatya Education and Research Hospital, Malatya, Turkey. Mesut Örtekus, Department of Anesthesiology and Reanimation, Malatya Turgut Özal University, Malatya, Turkey.
Copyright © 2022, Annals of Saudi Medicine, Saudi Arabia. This is an open access article under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND). The details of which can be accessed at http://creativecommons. org/licenses/by-nc-nd/4.0/
Delen, Leman Acuna, Department of Anesthesiology and Reanimation, Malatya Education and Research Hospital, Malatya, Turkey. Mesut Örtekus, Department of Anesthesiology and Reanimation, Malatya Turgut Özal University, Malatya, Turkey.
Anahtar Kelimeler
Kaynak
Annals of Saudi Medicine
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
42
Sayı
3
Künye
Delen, L. A., & Örtekus, M. (2022). Sinovac vaccination and the course of COVID-19 disease in hospitalized patients in Turkey. Annals of Saudi Medicine, 42(3), 147-154.
