Association between Platelet-to-Lymphocyte Ratio and Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome

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dc.contributor.authorDemircelik, Muhammed Bora
dc.contributor.authorKurtul, Alparslan
dc.contributor.authorOcek, Hakan
dc.contributor.authorCakmak, Muzaffer
dc.contributor.authorUreyen, Cagin
dc.contributor.authorEryonucu, Beyhan
dc.date.accessioned2025-10-24T18:09:28Z
dc.date.available2025-10-24T18:09:28Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: Contrast-induced nephropathy (CIN) is associated with significantly increased morbidity and mortality after percutaneous coronary intervention (PCI). Patients with acute coronary syndrome (ACS) are at higher risk of CIN. The platelet-to-lymphocyte ratio (PLR) is closely linked to inflammatory conditions. We hypothesized that PLR levels on admission can predict the development of CIN after PCI for ACS. Subjects and Methods: A total of 426 patients (mean age 63.17 +/- 13.01 years, 61.2% males) with ACS undergoing PCI were enrolled in this study. Admission PLR levels were measured before PCI. Serum creatinine values were measured before and within 72 h after the administration of contrast agents. Patients were divided into 2 groups: the CIN group and the no-CIN group. CIN was defined as an increase in serum creatinine level of >= 0.5 mg/dl or 25% above baseline within 72 h after contrast administration. Results: CIN developed in 53 patients (15.9%). Baseline PLR was significantly higher in patients who developed CIN compared to those who did not (160.8 +/- 29.7 and 135.1 +/- 26.1, respectively; p < 0.001). Multivariate analyses found that PLR [odds ratio (OR) 3.453 +/-, 95% confidence interval (CI) 1.453-8.543; p = 0.004] and admission creatinine (OR 6.511, 95% CI 1.759-11.095; p = 0.002) were independent predictors of CIN. Conclusions: The admission PLR level is an independent predictor of the development of CIN after PCI in ACS. (C) 2015 S. Karger AG, Basel
dc.identifier.doi10.1159/000371496
dc.identifier.endpage104
dc.identifier.issn1664-3828
dc.identifier.issn1664-5502
dc.identifier.issue2
dc.identifier.pmid25999958
dc.identifier.scopus2-s2.0-84928472331
dc.identifier.scopusqualityQ1
dc.identifier.startpage96
dc.identifier.urihttps://doi.org/10.1159/000371496
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3667
dc.identifier.volume5
dc.identifier.wosWOS:000353433100003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofCardiorenal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectHematological parameters; Platelet-to-lymphocyte ratio; Contrast-induced nephropathy; Acute coronary syndrome
dc.titleAssociation between Platelet-to-Lymphocyte Ratio and Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome
dc.title.alternativeAssociation between platelet-to-lymphocyte ratio and contrast-induced nephropathy in patients undergoing percutaneous coronary intervention for acute coronary syndrome
dc.typeArticle

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