Investigation of the Relationships Between IL-12B and IL-23 Receptor Polymorphisms with Behçet's Disease in a Turkish Population

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dc.contributor.authorArikan, Sanem
dc.contributor.authorOzturk, Onur
dc.contributor.authorAtalay, Ayfer
dc.contributor.authorAtalay, Erol Omer
dc.date.accessioned2026-06-19T06:37:44Z
dc.date.available2026-06-19T06:37:44Z
dc.date.issued2026
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBeh & ccedil;et's disease is a chronic, multisystem inflammatory disorder characterized by recurrent mucocutaneous and ocular manifestations, in which genetic factors, particularly cytokine gene polymorphisms, are thought to contribute to disease susceptibility. This study aimed to investigate the association of Interleukin-12B and Interleukin-23R gene polymorphisms and haplotype distributions with Beh & ccedil;et's disease in Denizli, a province of Turkey. A total of 88 patients with Beh & ccedil;et's disease and 133 healthy controls were genotyped for Interleukin-12B (rs3213119, rs3213120, rs3212227, rs3213113, rs2082412) and Interleukin-23R (rs1004819, rs7517847, rs7530511, rs10489629, rs10889677) polymorphisms using polymerase chain reaction-restriction fragment length polymorphism analysis. Genotype, allele, and haplotype distributions were evaluated for associations with Beh & ccedil;et's disease risk and clinical manifestations. The results demonstrated that the Interleukin-12B rs2082412 G allele and rs3213119 G allele were associated with increased risk of Beh & ccedil;et's disease. Additionally, the Interleukin-23R rs7530511 TT genotype and rs10489629 GG genotype and G allele were significantly associated with Beh & ccedil;et's disease susceptibility. Haplotype analyses revealed AAAGG and GTCAC as the most frequent haplotypes in Interleukin-12B and Interleukin-23R loci, respectively, in both patients and controls. These findings suggest that Interleukin-12B and Interleukin-23R gene polymorphisms and haplotypes may be associated with Beh & ccedil;et's disease susceptibility and clinical heterogeneity in this population.
dc.description.sponsorshipTUBITAK Project [SBAG-118S662, SBAG-113S163, SBAG-2388, PAU-ADEP/2017]; Researcher Support Project [2017KRM002-303]
dc.description.sponsorshipThis research was supported by the TUBITAK Project Numbers: SBAG-118S662, SBAG-113S163, and SBAG-2388 and PAU-ADEP/2017 Researcher Support Project No.: 2017KRM002-303.
dc.identifier.doi10.3390/ijms27020923
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.issue2
dc.identifier.orcid0000-0003-3404-4135
dc.identifier.pmid41596568
dc.identifier.scopus2-s2.0-105028711834
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/ijms27020923
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5201
dc.identifier.volume27
dc.identifier.wosWOS:001670609300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260612
dc.subjectBeh & Ccedil;Et'S Disease
dc.subjectInterleukin-12B
dc.subjectInterleukin-23R
dc.subjectHaplotype
dc.subjectSingle Nucleotide Polymorphism
dc.titleInvestigation of the Relationships Between IL-12B and IL-23 Receptor Polymorphisms with Behçet's Disease in a Turkish Population
dc.typeArticle

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