Is Kidney Injury Molecule 1 a Valuable Tool for the Early Diagnosis of Contrast-Induced Nephropathy?

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dc.authoridYildirim, Derya/0000-0003-2771-7725|Bilgic, Mukadder Ayse/0000-0003-0621-8273
dc.contributor.authorAkdeniz, Derya
dc.contributor.authorCelik, Huseyin Tugrul
dc.contributor.authorKazanci, Fatmanur
dc.contributor.authorYilmaz, Hakki
dc.contributor.authorYalcin, Serkan
dc.contributor.authorBilgic, Mukadder Ayse
dc.contributor.authorRuzgaresen, Nuket
dc.date.accessioned2025-10-24T18:09:18Z
dc.date.available2025-10-24T18:09:18Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAim/Scope Contrast-induced nephropathy (CIN) is a common complication of diagnostic/therapeutic procedures. Serum creatinine levels are sensitive but often lead to diagnostic delays in acute kidney injury and potential misclassification of actual injury status. Kidney injury molecule (KIM-1) is a novel early marker of acute kidney injury. The aim of our study was to evaluate the KIM-1 levels in patients with CIN. We performed a single-center, nested case-control study. Materials and Methods Three thousand two hundred patients who had undergone coronary angiography were included in the study. Thirty-two patients were diagnosed with CIN. Twenty patients who had undergone coronary angiography but did not have CIN were evaluated as a control group (n = 20). The diagnosis of CIN was performed according to the KDIGO 2012 Acute Kidney Injury Guideline criteria. Urinary KIM-1 levels were measured by enzyme-linked immunosorbent assay before as well as on the 6th and 48th hours of contrast exposure. Serum creatinine levels were measured before as well as on the 24th and 48th hours after angiographic procedure. Results We demonstrated that KIM-1 levels increased in the patients with CIN significantly on the sixth hour when compared with the baseline (P < 0.01; median levels, 0.27 and 0.70 mg/dL) but not in the controls (P = 0.107). The precontrast and 48th-hour KIM-1 levels were median ones and were also significantly different (P = 0.001, the median levels were 0.27 and 0.60 mg/dL, respectively). Conclusions Because creatinine is a sensitive but a late marker of CIN, KIM-1 may be used for early diagnosis and early initiation of treatment and may reduce risk for morbidity.
dc.identifier.doi10.1097/JIM.0000000000000243
dc.identifier.endpage934
dc.identifier.issn1081-5589
dc.identifier.issn1708-8267
dc.identifier.issue8
dc.identifier.pmid26474236
dc.identifier.scopus2-s2.0-84949035905
dc.identifier.scopusqualityQ2
dc.identifier.startpage930
dc.identifier.urihttps://doi.org/10.1097/JIM.0000000000000243
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3573
dc.identifier.volume63
dc.identifier.wosWOS:000365685800013
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmj Publishing Group
dc.relation.ispartofJournal Of Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectacute kidney Injury; contrast-induced nephropathy; kidney injury molecule 1
dc.titleIs Kidney Injury Molecule 1 a Valuable Tool for the Early Diagnosis of Contrast-Induced Nephropathy?
dc.title.alternativeIs kidney injury molecule 1 a valuable tool for the early diagnosis of contrast-induced nephropathy?
dc.typeArticle

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