Serum nesfatin-1 levels are decreased in pregnant women newly diagnosed with gestational diabetes

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dc.contributor.authorAdemoglu, Esra Nur
dc.contributor.authorGorar, Suheyla
dc.contributor.authorKeskin, Muge
dc.contributor.authorCarlioglu, Ayse
dc.contributor.authorUcler, Rifki
dc.contributor.authorErdamar, Husamettin
dc.contributor.authorCulha, Cavit
dc.date.accessioned2025-10-24T18:09:37Z
dc.date.available2025-10-24T18:09:37Z
dc.date.issued2017
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: To investigate serum nesfatin-1 levels at 24-28 weeks of pregnancy in women newly diagnosed with gestational diabetes and determine the association of nesfatin-1 with several metabolic parameters. Subjects and methods: Forty women newly diagnosed with gestational diabetes at 24-28 weeks of pregnancy and 30 healthy pregnant women matched in age and gestational week were included in this cross-sectional study. Serum nesfatin-1 levels were analyzed using ELISA, and the relationship between nesfatin-1 and several metabolic parameters were assessed. Results: Serum nesfatin-1 levels were found to be lower in women with gestational diabetes compared to the pregnant women in the control sample (p = 0.020). Multiple linear regression analysis revealed that nesfatin-1 was lower in participants with gestational diabetes independently from gestational age, BMI, HOMA-IR, fasting plasma glucose, and age. In correlation analysis, the only variable that was found to have a statistically significant correlation with nesfatin-1 was gestational age (p = 0.015, r = 0.30). Conclusion: Lower nesfatin-1 levels in women with gestational diabetes compared to the control group at 24-28 weeks of gestation draws attention to nesfatin-1 levels in gestational diabetes and motivates further research in this area.
dc.identifier.doi10.1590/2359-3997000000288
dc.identifier.endpage459
dc.identifier.issn2359-3997
dc.identifier.issn2359-4292
dc.identifier.issue5
dc.identifier.pmid28977160
dc.identifier.scopus2-s2.0-85042000062
dc.identifier.scopusqualityQ3
dc.identifier.startpage455
dc.identifier.urihttps://doi.org/10.1590/2359-3997000000288
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3741
dc.identifier.volume61
dc.identifier.wosWOS:000416002900008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSbem-Soc Brasil Endocrinologia & Metabologia
dc.relation.ispartofArchives Of Endocrinology Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectGestational diabetes; nesfatin-1; insulin resistance
dc.titleSerum nesfatin-1 levels are decreased in pregnant women newly diagnosed with gestational diabetes
dc.typeArticle

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