A novel association between TGF?1 and ADAMTS4 in coronary artery disease: A new potential mechanism in the progression of atherosclerosis and diabetes

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dc.authoridbatir, muhammet burak/0000-0002-8722-5055;
dc.contributor.authorUlucay, Safiye
dc.contributor.authorCam, Fethi Sirri
dc.contributor.authorBatir, Muhammed Burak
dc.contributor.authorSutcu, Recep
dc.contributor.authorBayturan, Ozgur
dc.contributor.authorDemircan, Kadir
dc.date.accessioned2025-10-24T18:10:03Z
dc.date.available2025-10-24T18:10:03Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: Coronary artery disease is characterized by atherosclerosis in the vessel wall. Recently, it has been thought that increasing LDL-binding capacity of subendothelial proteoglycan fragments that are formed by protease activity can be responsible for the initiation of atherosclerosis. ADAMTS4 is a member of the versican-degrading proteinases. In vitro studies demonstrated that TGF beta inhibits the expression of ADAMTS4 in macrophages. In this study, we aimed to investigate the role and association between TGF beta 1 and ADAMTS4 in coronary artery disease. Methods: A total of 84 cases with atheroma plaque and 72 controls without plaque were analyzed. The severity of disease was determined by Gensini score. TGF beta 1 gene polymorphisms were genotyped by the PCR-RFLP method. TGF beta 1 and ADAMTS4 serum levels were measured by ELISA method. Statistical analyses of genotypes and their relationship with serum levels were performed by chi-square, student t test and ANOVA. Results: ADAMTS4 levels were higher in cases compared with controls (p < 0.05). In the patient group, ADAMTS4 levels were higher than in controls and correlated with TGF beta 1 serum levels (r = 0.29; p < 0.05) and severity of disease (r = 0.20; p < 0.05). The TGF beta 1 gene CCA haplotype was associated with 3.3-fold increase in coronary artery disease (OR = 3.26 95% CI 1.22-8.68; p < 0.05). Unexpectedly, ADAMTS4 serum levels were also higher in diabetic cases (p = 0.05). Conclusion: This study has demonstrated that ADAMTS4 may be responsible for the pathogenesis of atherosclerosis. This is the first report about the association between ADAMTS4 and TGF beta 1 serum levels in the progression of atherosclerosis in CAD. Furthermore, it is seen that TGF beta 1 haplotype can cause a genetic susceptibility to CAD in the Turkish population. To our knowledge, this is also the first report suggesting higher serum ADAMTS4 levels in diabetic patients.
dc.identifier.doi10.5152/akd.2014.5762
dc.identifier.endpage829
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue10
dc.identifier.pmid25592103
dc.identifier.scopus2-s2.0-84988503940
dc.identifier.scopusqualityQ3
dc.identifier.startpage823
dc.identifier.urihttps://doi.org/10.5152/akd.2014.5762
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3964
dc.identifier.volume15
dc.identifier.wosWOS:000362968700008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Soc Cardiology
dc.relation.ispartofAnatolian Journal Of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectatherosclerosis; extracellular matrix; ADAMTS4; TGF beta 1 gene polymorphism; diabetes
dc.titleA novel association between TGF?1 and ADAMTS4 in coronary artery disease: A new potential mechanism in the progression of atherosclerosis and diabetes
dc.typeArticle

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