Changes of sFas and sFasL, oxidative stress markers in serum and follicular fluid of patients undergoing IVF

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dc.contributor.authorPekel, Aslihan
dc.contributor.authorGonenc, Aymelek
dc.contributor.authorTurhan, Nilgun Ozturk
dc.contributor.authorKafali, Hasan
dc.date.accessioned2025-10-24T18:08:50Z
dc.date.available2025-10-24T18:08:50Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThe Fas-Fas Ligand interaction is one of the essential events for the induction of apoptosis whereas the exact role of their soluble forms in the reproductive system is still not fully understood. Also oxidative stress in the pathogenesis of infertility causing diseases in women and has been suggested as one of the important factors that negatively affect IVF outcome. In this study, our aim was to evaluate serum and follicular fluid levels of soluble Fas soluble Fas Ligand, malondialdehyde, superoxide dismutase and total antioxidant capacity in patients undergoing IVF and compared with controls. This study included 109 patients. Patients were classified as unexplained infertility (N = 31), PCOS (N = 19), tubal factor (N = 9) and endometriosis (N = 10) and compared with male factor infertility (N = 40) that was the control group. sFas and sFasL levels were measured by immunoassay method. MDA, SOD and TAC levels were measured by colorimetric method. Patients with unexplained infertility, PCOS and tubal factor had significantly lower sFas levels compared with their controls (respectively, p < 0.01, p < 0.05, p < 0.05). However, SOD activity in unexplained infertility, PCOS and endometriosisgroupswere significantly higher than control group (p < 0.01).Decreased follicular fluid TAC levels were found in all patient groups compared with controls (respectively, p < 0.01, p < 0.05, p < 0.01, p < 0.01).Patients with tubal factor had significantly higher serum sFasL (p < 0.05), but lower follicular fluid sFasL levels (p < 0.05) compared with unexplained infertility. Tubal factor and endometriosis groups had lowerfollicular fluid TAC levels compared to unexplained infertility and PCOSgroups (p < 0.01). In this study, serum and follicular fluid sFas levels were decreased and antioxidant activity was impaired in infertility, possibly implying increased apoptosis. Especially in unexplained infertility group changes in this parametres more remarkable.
dc.description.sponsorshipGazi University Research Foundation [02/2011-36]
dc.description.sponsorshipThe work was supported by Gazi University Research Foundation (Project no. 02/2011-36). Our sincere thanks are due to Assoc. Prof. I. Safa Gurcan, Department of Biometry, Veterinary Faculty, Ankara University for the assistance in data analysis.
dc.identifier.doi10.1007/s10815-014-0396-8
dc.identifier.endpage241
dc.identifier.issn1058-0468
dc.identifier.issn1573-7330
dc.identifier.issue2
dc.identifier.pmid25488202
dc.identifier.scopus2-s2.0-84925500410
dc.identifier.scopusqualityQ1
dc.identifier.startpage233
dc.identifier.urihttps://doi.org/10.1007/s10815-014-0396-8
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3330
dc.identifier.volume32
dc.identifier.wosWOS:000350359400010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofJournal Of Assisted Reproduction And Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectsFas; sFasL; Oxidative stress; Antioxidant; IVF
dc.titleChanges of sFas and sFasL, oxidative stress markers in serum and follicular fluid of patients undergoing IVF
dc.typeArticle

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