Borax Partially Prevents Neurologic Disability and Oxidative Stress in Experimental Spinal Cord Ischemia/Reperfusion Injury

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dc.authoridKOC, EMINE RABIA/0000-0002-0264-7284;
dc.contributor.authorRabia, Emine
dc.contributor.authorGokce, Emre Cemal
dc.contributor.authorSonmez, Mehmet Akif
dc.contributor.authorNamuslu, Mehmet
dc.contributor.authorGokce, Aysun
dc.contributor.authorBodur, A. Said
dc.date.accessioned2025-10-24T18:09:05Z
dc.date.available2025-10-24T18:09:05Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjectives: The aim of this study is to investigate the potential effects of borax on ischemia/reperfusion injury of the rat spinal cord. Methods: Twenty-one Wistar albino rats were divided into 3 groups: sham (no ischemia/reperfusion), ischemia/reperfusion, and borax (ischemia/reperfusion + borax); each group was consist of 7 animals. Infrarenal aortic cross clamp was applied for 30 minutes to generate spinal cord ischemia. Animals were evaluated functionally with the Basso, Beattie, and Bresnahan scoring system and inclined-plane test. The spinal cord tissue samples were harvested to analyze tissue concentrations of nitric oxide, nitric oxide synthase activity, xanthine oxidase activity, total antioxidant capacity, and total oxidant status and to perform histopathological examination. Results: At the 72nd hour after ischemia, the borax group had significantly higher Basso, Beattie, and Bresnahan and inclined-plane scores than those of ischemia/reperfusion group. Histopathological examination of spinal cord tissues in borax group showed that treatment with borax significantly reduced the degree of spinal cord edema, inflammation, and tissue injury disclosed by light microscopy. Xanthine oxidase activity and total oxidant status levels of the ischemia/reperfusion group were significantly higher than those of the sham and borax groups (P >.05), and total antioxidant capacity levels of borax group were significantly higher than those of the ischemia/reperfusion group (P > .05). There was not a significantly difference between the sham and borax groups in terms of total antioxidant capacity levels (P > .05). The nitric oxide levels and nitric oxide synthase activity of all groups were similar (P >.05). Conclusions: Borax treatment seems to protect the spinal cord against injury in a rat ischemia/reperfusion model and improve neurological outcome.
dc.description.sponsorshipScientific Research Fund of Turgut Ozal University [P53011220 G]
dc.description.sponsorshipThis study was supported by the Scientific Research Fund of Turgut Ozal University with project number P53011220 G.
dc.identifier.doi10.1016/j.jstrokecerebrovasdis.2014.07.037
dc.identifier.endpage90
dc.identifier.issn1052-3057
dc.identifier.issn1532-8511
dc.identifier.issue1
dc.identifier.pmid25440351
dc.identifier.scopus2-s2.0-84920724153
dc.identifier.scopusqualityQ1
dc.identifier.startpage83
dc.identifier.urihttps://doi.org/10.1016/j.jstrokecerebrovasdis.2014.07.037
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3463
dc.identifier.volume24
dc.identifier.wosWOS:000346733700025
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofJournal Of Stroke & Cerebrovascular Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectBorax; spinal cord; ischemia; reperfusion injury; neuroprotection; oxidative stress
dc.titleBorax Partially Prevents Neurologic Disability and Oxidative Stress in Experimental Spinal Cord Ischemia/Reperfusion Injury
dc.title.alternativeBorax partially prevents neurologic disability and oxidative stress in experimental spinal cord ischemia/reperfusion injury
dc.typeArticle

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