Evaluation of ocular pulse amplitude and choroidal thickness in diabetic macular edema

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dc.contributor.authorTotan, Y.
dc.contributor.authorAkyuz, T. K.
dc.contributor.authorGuler, E.
dc.contributor.authorGuragac, F. B.
dc.date.accessioned2025-10-24T18:09:12Z
dc.date.available2025-10-24T18:09:12Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurpose The aim of this study is to evaluate the ocular pulse amplitude (OPA) and choroidal thickness (CT) measurements in patients with diabetic macular edema (DME) and healthy subjects. Methods A total of 34 patients (12 male and 22 female) who had type 2 diabetes mellitus with DME and 34 sex-matched healthy subjects (13 male and 21 female) were included in this prospective study. The intraocular pressure (IOP) and OPA were measured with Dynamic contour tonometer (Pascal DCT, Switzerland). The subfoveal CT was measured using the Cirrus HD-OCT (Carl Zeiss Meditec). The CT at 1500 mu m and 3000 mu m nasal and temporal to the central fovea was also measured. Results The mean IOP values were 18.4 +/- 3.5 and 17.1 +/- 2.1mmHg in DME patients and healthy controls, respectively (P = 0.091). The mean OPA values in patients with DME (2.58 +/- 0.96) and controls (3.52 +/- 1.03) were statistically different (P < 0.001). The mean subfoveal CT value was 273.5 +/- 30.2 mu m in the eyes with DME and 321.4 +/- 36.5 mu m in the control group (P < 0.001). In both groups, linear regression analysis showed no significant association between OPA and CT measurements. The IOP showed a significantly positive correlation with OPA in both DME (P = 0.002, r = 0.526) and controls (P = 0.004, r = 0.483). Conclusions The current study suggests that both pulsatile choroidal blood flow and CT are decreased in patients with DME.
dc.identifier.doi10.1038/eye.2015.232
dc.identifier.endpage374
dc.identifier.issn0950-222X
dc.identifier.issn1476-5454
dc.identifier.issue3
dc.identifier.pmid26563658
dc.identifier.scopus2-s2.0-85015132681
dc.identifier.scopusqualityQ1
dc.identifier.startpage369
dc.identifier.urihttps://doi.org/10.1038/eye.2015.232
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3514
dc.identifier.volume30
dc.identifier.wosWOS:000373490500007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.ispartofEye
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectOptical Coherence Tomography; Dynamic Contour Tonometry; Pneumatic Applanation Tonometer; Growth-Factor Therapy; Diurnal-Variation; Retinopathy
dc.titleEvaluation of ocular pulse amplitude and choroidal thickness in diabetic macular edema
dc.typeArticle

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