The Effect of Isotretinoin on Retinol-Binding Protein 4, Leptin, Adiponectin and Insulin Resistance in Acne Vulgaris Patients

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dc.authoridTakci, Zennure/0000-0001-7257-5792
dc.contributor.authorKaradag, Ayse Serap
dc.contributor.authorErtugrul, Derun Taner
dc.contributor.authorTakci, Zennure
dc.contributor.authorBilgili, Serap Gunes
dc.contributor.authorNamuslu, Mehmet
dc.contributor.authorAta, Naim
dc.contributor.authorSekeroglu, Ramazan
dc.date.accessioned2025-10-24T18:09:28Z
dc.date.available2025-10-24T18:09:28Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground: The effect of isotretinoin (ISO) on adipokines and insulin resistance has been investigated in a few studies, and the results are conflicting. Objective: The aim of this study was to investigate the effect of ISO treatment on insulin resistance and adipokines. Methods: Thirty-three patients with acne vulgaris and a control group of 30 healthy volunteers were included in our study. Screening for the biochemical parameters was performed just before the initiation and after 3 months of ISO treatment. Results: In the acne group, basal leptin levels were significantly lower (p = 0.003) and basal adiponectin levels significantly higher (p = 0.008) compared with the control group. After ISO treatment, leptin levels (p = 0.0005) decreased and adiponectin levels (p = 0.003) increased significantly. However, measurements of fasting blood glucose, insulin, C peptide, retinol-binding protein 4 (RBP4), homeostasis model assessment insulin re-sistance and BMI did not differ after ISO treatment. Conclusion: ISO may affect leptin and adiponectin levels. It does not, however, affect insulin resistance and RBP4 levels. (C) 20155. Karger AG, Basel
dc.description.sponsorshipYuzuncu Yil University Scientific Research Project [TF-B017]
dc.description.sponsorshipThis study was supported by the Yuzuncu Yil University Scientific Research Project (TF-B017, 2011).
dc.identifier.doi10.1159/000367687
dc.identifier.endpage74
dc.identifier.issn1018-8665
dc.identifier.issn1421-9832
dc.identifier.issue1
dc.identifier.pmid25573071
dc.identifier.scopus2-s2.0-84922981283
dc.identifier.scopusqualityQ1
dc.identifier.startpage70
dc.identifier.urihttps://doi.org/10.1159/000367687
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3666
dc.identifier.volume230
dc.identifier.wosWOS:000349514500014
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKarger
dc.relation.ispartofDermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectAcne vulgaris; Adipokines; Insulin resistance; Isotretinoin
dc.titleThe Effect of Isotretinoin on Retinol-Binding Protein 4, Leptin, Adiponectin and Insulin Resistance in Acne Vulgaris Patients
dc.title.alternativeThe effect of isotretinoin on retinol-binding protein 4, leptin, adiponectin and insulin resistance in acne vulgaris patients
dc.typeArticle

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