Effect of smoking on retina nerve fiber layer and ganglion cell-inner plexiform layer complex

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dc.authoriddervisogullari, mehmet serdar/0000-0003-2006-2906;
dc.contributor.authorDervisogullari, Mehmet Serdar
dc.contributor.authorTotan, Yuksel
dc.contributor.authorTenlik, Aylin
dc.contributor.authorYuce, Aslihan
dc.contributor.authorGuler, Emre
dc.date.accessioned2025-10-24T18:09:45Z
dc.date.available2025-10-24T18:09:45Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurpose: The aim of this study is to show the effects of smoking on retina layers, especially retina nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer complex (GCIPL). Materials and methods: Participants smoking for more than 10 years at least 1 pack of cigarettes a day and a control group, both including participants between ages of 20 and 50 years with no other systemic or ocular diseases were studied. After normality tests, an independent sample t test was used to analyze the differences in age, sex, spherical equivalent (SE), intraocular pressure (IOP), axial length (AL), GCIPL and RNFL values between the groups. Results: There were 44 participants in each group. There were 32 (62.5%) men and 12(37.5%) women in smokers and 36 (77.88%) men and 8 (22.22%) women in control group. Mean ages were 39.85 +/- 8.41 and 38.66 +/- 10.47 years, mean spherical equivalent (SE) values were +/- 0.15 +/- 0.4 and 0 +/- 0.29 dioptries in smokers and control groups, respectively. The IOP, AXL, GCIPL and RNFL values were 17.58 +/- 3.41 mmHg, 23.69 +/- 0.56 mm, 84.3 +/- 5.83 mu m and 92.3 +/- 3.51 mu m in the smokers group and 18.5 +/- 2.91 mmHg, 23.45 +/- 0.72 mm, 86.11 +/- 8.02 mu m and 97.66 +/- 8.23 mu m in the control group. The inferior, superior, nasal and temporal values of RNFL quadrants were 123.18 +/- 26.14, 117.05 +/- 5.51, 64.95 +/- 8.67 and 63.5 +/- 6.88 mu m in the smokers group and 130.81 +/- 11.8, 123.55 +/- 11.03, 72.44 +/- 9.84 and 58.44 +/- 7.48 mu m in the control group. There were no significant difference of age, sex, SE, IOP, AXL and GCIPL values between the smokers and control groups (p>0.05). The mean RNFL was significantly thinner in the smokers group compared to controls (p = 0.03, independent t test). Inferior and superior quadrants of RNFL decreased in smokers group (p = 0.01 and p = 0.03, respectively) but temporal and nasal quadrants did not seem to be changed (p = 0.96 and p = 0.07, respectively). Discussion: Smoking may affect RNFL thickness but not GCIPL.
dc.identifier.doi10.3109/15569527.2014.975240
dc.identifier.endpage285
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue4
dc.identifier.pmid25363066
dc.identifier.scopus2-s2.0-84946027471
dc.identifier.scopusqualityQ3
dc.identifier.startpage282
dc.identifier.urihttps://doi.org/10.3109/15569527.2014.975240
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3810
dc.identifier.volume34
dc.identifier.wosWOS:000371395000004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofCutaneous And Ocular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectGanglion cell; inner plexiform layer complex; retinal nerve fiber layer; smoking
dc.titleEffect of smoking on retina nerve fiber layer and ganglion cell-inner plexiform layer complex
dc.typeArticle

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