Neuroprotective effect of atorvastatin in spinal cord ischemia-reperfusion injury

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dc.contributor.authorNazli, Yunus
dc.contributor.authorColak, Necmettin
dc.contributor.authorAlpay, Mehmet Fatih
dc.contributor.authorUysal, Sema
dc.contributor.authorUzunlar, Ali Kemal
dc.contributor.authorCakir, Omer
dc.date.accessioned2025-10-24T18:10:13Z
dc.date.available2025-10-24T18:10:13Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractOBJECTIVES: Prevention of the development of paraplegia during the repair of the damage caused by descending thoracic and thoracoabdominal aneurysms remains an important issue. Therefore, we investigated the protective effect of atorvastatin on ischemia-induced spinal cord injury in a rabbit model. METHOD: Thirty-two rabbits were divided into the following four equally sized groups: group I (control), group II (ischemia-reperfusion), group III (atorvastatin treatment) and group IV (atorvastatin withdrawal). Spinal cord ischemia was induced by clamping the aorta both below the left renal artery and above the iliac bifurcation. Seventy-two hours postoperatively, the motor function of the lower limbs of each animal was evaluated according to the Tarlov score. Spinal cord and blood samples were obtained for histopathological and biochemical analyses. RESULTS: All of the rabbits in group II exhibited severe neurological deficits. Atorvastatin treatment (groups III and IV) significantly reduced the level of motor dysfunction. No significant differences were observed between the motor function scores of groups III and IV at the evaluated time points. Light microscopic examination of spinal cord tissue samples obtained at the 72nd hour of reperfusion indicated greater tissue preservation in groups III and IV than in group II. CONCLUSION: This study demonstrates the considerable neuroprotective effect of atorvastatin on the neurological, biochemical and histopathological status of rabbits with ischemia-induced spinal cord injury. Moreover, the acute withdrawal of atorvastatin therapy following the induction of spinal cord ischemia did not increase the neuronal damage in this rabbit model.
dc.identifier.doi10.6061/clinics/2015(01)10
dc.identifier.endpage60
dc.identifier.issn1807-5932
dc.identifier.issn1980-5322
dc.identifier.issue1
dc.identifier.pmid25672430
dc.identifier.scopus2-s2.0-84922349890
dc.identifier.scopusqualityQ1
dc.identifier.startpage52
dc.identifier.urihttps://doi.org/10.6061/clinics/2015(01)10
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4048
dc.identifier.volume70
dc.identifier.wosWOS:000349619500010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHospital Clinicas, Univ Sao Paulo
dc.relation.ispartofClinics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectAtorvastatin; Spinal Cord; Ischemia-Reperfusion Injury
dc.titleNeuroprotective effect of atorvastatin in spinal cord ischemia-reperfusion injury
dc.typeArticle

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