Adipokine, adropin and endothelin-1 levels in intrauterine growth restricted neonates and their mothers

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dc.authoridKaygusuz, Ikbal/0000-0002-5635-505X|Ozkan-Yildirim, Sevgi/0000-0002-7603-3656|AYDIN, Halil Ibrahim/0000-0001-7994-4394;
dc.contributor.authorAydin, Halil Ibrahim
dc.contributor.authorEser, Ayla
dc.contributor.authorKaygusuz, Ikbal
dc.contributor.authorYildirim, Sevgi
dc.contributor.authorCelik, Tugrul
dc.contributor.authorGunduz, Suzan
dc.contributor.authorKalman, Suleyman
dc.date.accessioned2025-10-24T18:09:36Z
dc.date.available2025-10-24T18:09:36Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractIntrauterine growth retardation/restriction (IUGR) is associated with fetal malnutrition. It has consequences for later life including increased incidence of obesity, diabetes mellitus, cardiovascular disease (CVD), and metabolic syndrome. Adipokines (adiponectin and leptin), adropin, and endothelin-1 are associated with obesity and metabolic syndrome regulation. Intrauterine changes in these mediators could affect programming of later adult obesity and metabolic syndrome. Our objectives were to compare the levels of these mediators in both cord and maternal blood between IUGR pregnancies and control, healthy pregnancies, and to study the correlation of adipokines with adropin and endothelin-1 in maternal and cord blood in IUGR pregnancies as well as in healthy control pregnancies. Maternal and cord blood samples were taken from 16 women with IUGR pregnancies and 16 women with healthy pregnancies. Serum levels of leptin, adiponectin, adropin, and endothelin-1 were measured by ELISA. Maternal blood adropin levels were significantly lower in the IUGR group than in the control group; the other mediators did not differ significantly. There was a positive correlation between maternal blood adropin and endothelin levels. (r = 0.731, P = 0.001) in the control but not the IUGR group. Cord blood adropin and adiponectin levels were significantly lower in the IUGR group compared with the control group, while leptin or endothelin-1 did not differ significantly. There was a negative correlation between adropin and leptin (r = -0.704, P = 0.001) in the IUGR but not the control group cord blood. There were also positive correlations between endothelin and adropin for both groups (r = 0.594, P = 0.006; r = 0.560, P = 0.010, respectively); to the best of our knowledge, this is the first report of such a correlation. Differences in fetal expression of adropin and adiponectin in IUGR could influence programming of obesity, metabolic syndrome, diabetes, and CVD in later life.
dc.identifier.doi10.1515/jpm-2014-0353
dc.identifier.endpage676
dc.identifier.issn0300-5577
dc.identifier.issn1619-3997
dc.identifier.issue6
dc.identifier.pmid26352058
dc.identifier.scopus2-s2.0-84983350372
dc.identifier.scopusqualityQ1
dc.identifier.startpage669
dc.identifier.urihttps://doi.org/10.1515/jpm-2014-0353
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3734
dc.identifier.volume44
dc.identifier.wosWOS:000381016200010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofJournal Of Perinatal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectAdiponectin; adropin; endothelin-1; intrauterine growth retardation; leptin; newborn; pregnancy
dc.titleAdipokine, adropin and endothelin-1 levels in intrauterine growth restricted neonates and their mothers
dc.typeArticle

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